Synthesis, characterization and in vitro cytotoxicity of gold(III) dialkyl/diaryldithiocarbamato complexes

Kód výsledku v IS VaVaI

RIV/61989592:15310/15:33156318 - isvavai.cz

Výsledek na webu

http://pubs.rsc.org/en/content/articlepdf/2015/ra/c5ra15123f

DOI - Digital Object Identifier

10.1039/c5ra15123f

Jazyk výsledku

angličtina

Název v původním jazyce

Synthesis, characterization and in vitro cytotoxicity of gold(III) dialkyl/diaryldithiocarbamato complexes

Popis výsledku v původním jazyce

A series of six dialkyl/diaryldithiocarbamato (dtc) gold(III) complexes 1- 6 of the composition [Au(Me(2)dtc)(2)]Cl (1), [Au(Me(2)dtc)Cl-2] (2), [Au(Et(2)dtc)(2)]Cl (3), [Au(Et(2)dtc)Cl-2] (4), [Au(Bn(2)dtc)(2)]Cl (5), [Au(Bn(2)dtc)Cl-2] (6) (dtc = Dithiocarbamate, Me = Methyl, Et = Ethyl and Bn = Benzyl) was synthesised and characterized by elemental analysis, infrared and NMR spectroscopy, and single crystal X-ray analysis in the case of complexes 4 and 5. The anticancer potential of the complexes wasevaluated against MCF7, A2780 and A2780R human cancer cell lines as well as against a healthy MRC5 cell line. The most promising data were obtained for complex 4. It showed similar cytotoxicity as cisplatin against A2780 cells (EC50 approximate to 9.5 mu M vs. EC50 approximate to 10 mu M), and significantly higher cytotoxicity as compared to cisplatin on A2780R and MCF7 cell lines, with EC50 approximate to 2.8 mu M vs. EC50 approximate to 21 mu M, and EC50 approximate to 2.2 mu M vs. EC

Název v anglickém jazyce

Synthesis, characterization and in vitro cytotoxicity of gold(III) dialkyl/diaryldithiocarbamato complexes

Popis výsledku anglicky

A series of six dialkyl/diaryldithiocarbamato (dtc) gold(III) complexes 1- 6 of the composition [Au(Me(2)dtc)(2)]Cl (1), [Au(Me(2)dtc)Cl-2] (2), [Au(Et(2)dtc)(2)]Cl (3), [Au(Et(2)dtc)Cl-2] (4), [Au(Bn(2)dtc)(2)]Cl (5), [Au(Bn(2)dtc)Cl-2] (6) (dtc = Dithiocarbamate, Me = Methyl, Et = Ethyl and Bn = Benzyl) was synthesised and characterized by elemental analysis, infrared and NMR spectroscopy, and single crystal X-ray analysis in the case of complexes 4 and 5. The anticancer potential of the complexes wasevaluated against MCF7, A2780 and A2780R human cancer cell lines as well as against a healthy MRC5 cell line. The most promising data were obtained for complex 4. It showed similar cytotoxicity as cisplatin against A2780 cells (EC50 approximate to 9.5 mu M vs. EC50 approximate to 10 mu M), and significantly higher cytotoxicity as compared to cisplatin on A2780R and MCF7 cell lines, with EC50 approximate to 2.8 mu M vs. EC50 approximate to 21 mu M, and EC50 approximate to 2.2 mu M vs. EC

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CA - Anorganická chemie

OECD FORD obor

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Projekt

LO1305: Rozvoj centra pokročilých technologií a materiálů

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

RSC Advances (online)

ISSN

2046-2069

e-ISSN

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Svazek periodika

5

Číslo periodika v rámci svazku

99

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

81599-81607

Kód UT WoS článku

000362436800084

EID výsledku v databázi Scopus

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