Enantiomeric separation of tapentadol by capillary electrophoresis-Study of chiral selectivity manipulation by various types of cyclodextrins

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F15%3A33156326" target="_blank" >RIV/61989592:15310/15:33156326 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S0731708514005548" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0731708514005548</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jpba.2014.11.027" target="_blank" >10.1016/j.jpba.2014.11.027</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Enantiomeric separation of tapentadol by capillary electrophoresis-Study of chiral selectivity manipulation by various types of cyclodextrins

Popis výsledku v původním jazyce

The chiral recognition of the centrally acting analgesic agent tapentadol and its isomers with various cyclodextrins (CDs) was studied by capillary electrophoresis, focusing on the migration order of four stereoisomers. In the case of non-charged hydroxypropylated CDs (2-hydroxypropyl-beta-CD, 2-hydroxypropyl-gamma-CD) the beta derivative was able to discriminate the S,R- and R,S-isomers in acidic background electrolyte, whereas the gamma allowed the separation of S,S- and R,R-tapentadol, respectively.Dual CD system containing both hosts was used to separate all of four isomers. Negatively charged sulfated-alpha-CD at 1.0% (w/v) concentration in 100 mM sodium borate buffer (pH 9.5) was capable of separating the isomers with favorable enantiomer migration order and the optimized method was able to determine 0.15% of chiral impurities of tapentadol in the presence of the last migrating clinically important R,R-isomer

Název v anglickém jazyce

Enantiomeric separation of tapentadol by capillary electrophoresis-Study of chiral selectivity manipulation by various types of cyclodextrins

Popis výsledku anglicky

The chiral recognition of the centrally acting analgesic agent tapentadol and its isomers with various cyclodextrins (CDs) was studied by capillary electrophoresis, focusing on the migration order of four stereoisomers. In the case of non-charged hydroxypropylated CDs (2-hydroxypropyl-beta-CD, 2-hydroxypropyl-gamma-CD) the beta derivative was able to discriminate the S,R- and R,S-isomers in acidic background electrolyte, whereas the gamma allowed the separation of S,S- and R,R-tapentadol, respectively.Dual CD system containing both hosts was used to separate all of four isomers. Negatively charged sulfated-alpha-CD at 1.0% (w/v) concentration in 100 mM sodium borate buffer (pH 9.5) was capable of separating the isomers with favorable enantiomer migration order and the optimized method was able to determine 0.15% of chiral impurities of tapentadol in the presence of the last migrating clinically important R,R-isomer

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Pharmaceutical and Biomedical Analysis

ISSN

0731-7085

e-ISSN

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Svazek periodika

105

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

10-16

Kód UT WoS článku

000349064600002

EID výsledku v databázi Scopus

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