High-performance liquid chromatographic separation of unusual beta(3)-amino acid enantiomers in different chromatographic modes on Cinchona alkaloid-based zwitterionic chiral stationary phases

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F15%3A33156862" target="_blank" >RIV/61989592:15310/15:33156862 - isvavai.cz</a>

Výsledek na webu

<a href="http://link.springer.com/article/10.1007%2Fs00726-015-2006-1" target="_blank" >http://link.springer.com/article/10.1007%2Fs00726-015-2006-1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00726-015-2006-1" target="_blank" >10.1007/s00726-015-2006-1</a>

Jazyk výsledku

angličtina

Název v původním jazyce

High-performance liquid chromatographic separation of unusual beta(3)-amino acid enantiomers in different chromatographic modes on Cinchona alkaloid-based zwitterionic chiral stationary phases

Popis výsledku v původním jazyce

Polar-ionic and hydro-organic mobile phase mode of high-performance liquid chromatographic separations of 23 sterically constrained primary beta(3)-amino acid enantiomers containing, alkyl, aryl or heteroaryl side-chains were carried out by using newly developed Cinchona alkaloid-based zwitterionic chiral selectors and the stationary phases Chiralpak ZWIX(+)(TM) and ZWIX(-)(TM). In the polar-ionic mode, the effects of the composition of the bulk solvent and the natures of the co- and counter-ions, whilein the hydro-organic mode, the effects of the pH, the counter-ion concentration and the structures of the analytes were investigated. The separations of the enantiomers of these 23 primary beta(3)-amino acids, which can be classified as a series of quasi- (pseudo-) homologs, were optimized in both chromatographic modes. The elution sequence was determined in most cases and a reversal of elution order on ZWIX(+)(TM) and ZWIX(-)(TM) column was observed. On the basis of this intermolecular

Název v anglickém jazyce

High-performance liquid chromatographic separation of unusual beta(3)-amino acid enantiomers in different chromatographic modes on Cinchona alkaloid-based zwitterionic chiral stationary phases

Popis výsledku anglicky

Polar-ionic and hydro-organic mobile phase mode of high-performance liquid chromatographic separations of 23 sterically constrained primary beta(3)-amino acid enantiomers containing, alkyl, aryl or heteroaryl side-chains were carried out by using newly developed Cinchona alkaloid-based zwitterionic chiral selectors and the stationary phases Chiralpak ZWIX(+)(TM) and ZWIX(-)(TM). In the polar-ionic mode, the effects of the composition of the bulk solvent and the natures of the co- and counter-ions, whilein the hydro-organic mode, the effects of the pH, the counter-ion concentration and the structures of the analytes were investigated. The separations of the enantiomers of these 23 primary beta(3)-amino acids, which can be classified as a series of quasi- (pseudo-) homologs, were optimized in both chromatographic modes. The elution sequence was determined in most cases and a reversal of elution order on ZWIX(+)(TM) and ZWIX(-)(TM) column was observed. On the basis of this intermolecular

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

—

Projekt

<a href="/cs/project/LO1305" target="_blank" >LO1305: Rozvoj centra pokročilých technologií a materiálů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Amino Acids

ISSN

0939-4451

e-ISSN

—

Svazek periodika

47

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

AT - Rakouská republika

Počet stran výsledku

13

Strana od-do

2279-2291

Kód UT WoS článku

000363481100004

EID výsledku v databázi Scopus

—