Direct high-performance liquid chromatographic enantioseparation of free alpha-, beta- and gamma-aminophosphonic acids employing cinchona-based chiral zwitterionic ion exchangers

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F13%3A33147292" target="_blank" >RIV/61989592:15310/13:33147292 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s00216-013-6938-6" target="_blank" >http://dx.doi.org/10.1007/s00216-013-6938-6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00216-013-6938-6" target="_blank" >10.1007/s00216-013-6938-6</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Direct high-performance liquid chromatographic enantioseparation of free alpha-, beta- and gamma-aminophosphonic acids employing cinchona-based chiral zwitterionic ion exchangers

Popis výsledku v původním jazyce

We report a chiral high-performance liquid chromatographic enantioseparation method for free alpha-aminophosphonic, beta-aminophosphonic, and gamma-aminophosphonic acids, aminohydroxyphosphonic acids, and aromatic aminophosphinic acids with different substitution patterns. Enantioseparation of these synthons was achieved by means of high-performance liquid chromatography on CHIRALPAK ZWIX(+) and ZWIX(-) (cinchona-based chiral zwitterionic ion exchangers) under polar organic chromatographic elution conditions. Mobile phase characteristics such as acid-to-base ratio, type of counterion, and solvent composition were systematically varied in order to investigate their effect on the separation performance and to achieve optimal separation conditions for theset of analytes. Under the optimized conditions, 32 of 37 racemic aminophosphonic acids studied reached baseline separation when we employed a single generic mass-spectrometry-compatible mobile phase, with reversal of the elution order w

Název v anglickém jazyce

Direct high-performance liquid chromatographic enantioseparation of free alpha-, beta- and gamma-aminophosphonic acids employing cinchona-based chiral zwitterionic ion exchangers

Popis výsledku anglicky

We report a chiral high-performance liquid chromatographic enantioseparation method for free alpha-aminophosphonic, beta-aminophosphonic, and gamma-aminophosphonic acids, aminohydroxyphosphonic acids, and aromatic aminophosphinic acids with different substitution patterns. Enantioseparation of these synthons was achieved by means of high-performance liquid chromatography on CHIRALPAK ZWIX(+) and ZWIX(-) (cinchona-based chiral zwitterionic ion exchangers) under polar organic chromatographic elution conditions. Mobile phase characteristics such as acid-to-base ratio, type of counterion, and solvent composition were systematically varied in order to investigate their effect on the separation performance and to achieve optimal separation conditions for theset of analytes. Under the optimized conditions, 32 of 37 racemic aminophosphonic acids studied reached baseline separation when we employed a single generic mass-spectrometry-compatible mobile phase, with reversal of the elution order w

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

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Projekt

<a href="/cs/project/ED2.1.00%2F03.0058" target="_blank" >ED2.1.00/03.0058: Regionální centrum pokročilých technologií a materiálů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Analytical and Bioanalytical Chemistry

ISSN

1618-2642

e-ISSN

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Svazek periodika

405

Číslo periodika v rámci svazku

25

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

12

Strana od-do

8027-8038

Kód UT WoS článku

000324587400010

EID výsledku v databázi Scopus

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