Polymorphic effects of FABP4 and SCD genes on intramuscular fatty acid profiles from two cattle breeds

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F15%3A33157260" target="_blank" >RIV/61989592:15310/15:33157260 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Polymorphic effects of FABP4 and SCD genes on intramuscular fatty acid profiles from two cattle breeds

Popis výsledku v původním jazyce

The aim of this study was to evaluate the genetic variability of two single nucleotide polymorphisms (SNPs) of fatty acid binding protein (FABP4) and stearoyl-CoA desaturase (SCD) genes. Two previously reported SNPs of bovine FABP4 (7516G>C) and SCD (878C>T) were in turn assessed for their associations with intramuscular fatty acid profiles from the upper sirloin cuts of Aberdeen Angus and Blonde d'Aquitaine cattle. In total, 33 animals were genotyped using PCR-RFLP. Intramuscular fatty acid compositionwas evaluated using two complementary statistical approaches: a classical univariate regression model and a multivariate approach using a combination of Principal Component Analysis and Random Forests. Significant effect of FABP4 SNP genotypes was foundfor several fatty acids including C15:0, C17:0, C18:0, C14:1, C17:1, C18:2n6, C20:4n6, C20:5n3, C22:5n3, total n-3, n-6, n-3/n-6 ratio and total SFA (P < 0.05). These results suggest that FABP4 is a potential candidate gene affecting fat

Název v anglickém jazyce

Polymorphic effects of FABP4 and SCD genes on intramuscular fatty acid profiles from two cattle breeds

Popis výsledku anglicky

The aim of this study was to evaluate the genetic variability of two single nucleotide polymorphisms (SNPs) of fatty acid binding protein (FABP4) and stearoyl-CoA desaturase (SCD) genes. Two previously reported SNPs of bovine FABP4 (7516G>C) and SCD (878C>T) were in turn assessed for their associations with intramuscular fatty acid profiles from the upper sirloin cuts of Aberdeen Angus and Blonde d'Aquitaine cattle. In total, 33 animals were genotyped using PCR-RFLP. Intramuscular fatty acid compositionwas evaluated using two complementary statistical approaches: a classical univariate regression model and a multivariate approach using a combination of Principal Component Analysis and Random Forests. Significant effect of FABP4 SNP genotypes was foundfor several fatty acids including C15:0, C17:0, C18:0, C14:1, C17:1, C18:2n6, C20:4n6, C20:5n3, C22:5n3, total n-3, n-6, n-3/n-6 ratio and total SFA (P < 0.05). These results suggest that FABP4 is a potential candidate gene affecting fat

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

GI - Šlechtění a plemenářství hospodářských zvířat

OECD FORD obor

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Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Acta veterinaria Brno

ISSN

0001-7213

e-ISSN

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Svazek periodika

84

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

10

Strana od-do

327-336

Kód UT WoS článku

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EID výsledku v databázi Scopus

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