Dinuclear metal(II)-acetato complexes based on bicompartmental 4-chlorophenolate: syntheses, structures, magnetic properties, DNA interactions and phosphodiester hydrolysis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F16%3A33161122" target="_blank" >RIV/61989592:15310/16:33161122 - isvavai.cz</a>

Výsledek na webu

<a href="http://pubs.rsc.org/en/content/articlepdf/2016/dt/c6dt02596j" target="_blank" >http://pubs.rsc.org/en/content/articlepdf/2016/dt/c6dt02596j</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/c6dt02596j" target="_blank" >10.1039/c6dt02596j</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Dinuclear metal(II)-acetato complexes based on bicompartmental 4-chlorophenolate: syntheses, structures, magnetic properties, DNA interactions and phosphodiester hydrolysis

Popis výsledku v původním jazyce

A series of dinuclear metal(II)-acetato complexes: [Ni-2(mu-(LO)-O-Cl)(mu(2)-OAc)(2)](PF6)center dot 3H(2)O (1), [Ni-2(mu-(LO)-O-Cl)(mu(2)-OAc)(2)](ClO4)center dot CH3COCH3 (2), [Cu-2(mu-(LO)-O-Cl)(mu(2)-OAc)(ClO4)](ClO4) (3), [Cu-2(mu-(LO)-O-Cl)(OAc)(2)](PF6)center dot H2O (4), [Zn-2(mu-(LO)-O-Cl)(mu(2)-OAc)(2)](PF6) (5) and [Mn-2(L-Cl-O)(mu(2)-OAc)(2)](ClO4)center dot H2O (6), where (LO-)-O-Cl = 2,6-bis[bis(2-pyridylmethyl)aminomethyl]-4-chlorophenolate, were synthesized. The complexes were structurally characterized by spectroscopic techniques and single crystal X-ray crystallography. Six-coordinate geometries with doubly bridged acetato ligands were found in Ni(II), Zn(II) and Mn(II) complexes 1, 2, 5 and 6, whereas with Cu(II) complexes a five-coordinate species was obtained with 4, and mixed five-and six-coordinate geometries with a doubly bridged dimetal core were observed in 3. The magnetic properties of complexes 1-4 and 6 were studied at variable temperatures and revealed weak to very weak antiferromagnetic interactions in 1, 2, 4 and 6 (J = -0.55 to -9.4 cm(-1)) and ferromagnetic coupling in 3 (J = 15.4 cm(-1)). These results are consistent with DFT calculations performed at the B3LYP/def2-TZVP(-f) level of theory. Under physiological conditions, the interaction of the dinculear complexes 1-5 with supercoiled plasmid ds-DNA did not show any pronounced nuclease activity, but Ni(II) complexes 1 and 2 revealed a strong ability to unwind the supercoiled conformation of ds-DNA. The mechanistic studies performed on the interaction of the Ni(II) complexes with DNA demonstrated the important impact of the nickel(II) ion in the unwinding process. In combination with the DNA study, the phosphatase activity of complexes 1, 3, and 5 was examined by the phosphodiester hydrolysis of bis(2,4-dinitrophenol) phosphate (BDNPP) in the pH range of 5.5-10.5 at 25 degrees C.

Název v anglickém jazyce

Dinuclear metal(II)-acetato complexes based on bicompartmental 4-chlorophenolate: syntheses, structures, magnetic properties, DNA interactions and phosphodiester hydrolysis

Popis výsledku anglicky

A series of dinuclear metal(II)-acetato complexes: [Ni-2(mu-(LO)-O-Cl)(mu(2)-OAc)(2)](PF6)center dot 3H(2)O (1), [Ni-2(mu-(LO)-O-Cl)(mu(2)-OAc)(2)](ClO4)center dot CH3COCH3 (2), [Cu-2(mu-(LO)-O-Cl)(mu(2)-OAc)(ClO4)](ClO4) (3), [Cu-2(mu-(LO)-O-Cl)(OAc)(2)](PF6)center dot H2O (4), [Zn-2(mu-(LO)-O-Cl)(mu(2)-OAc)(2)](PF6) (5) and [Mn-2(L-Cl-O)(mu(2)-OAc)(2)](ClO4)center dot H2O (6), where (LO-)-O-Cl = 2,6-bis[bis(2-pyridylmethyl)aminomethyl]-4-chlorophenolate, were synthesized. The complexes were structurally characterized by spectroscopic techniques and single crystal X-ray crystallography. Six-coordinate geometries with doubly bridged acetato ligands were found in Ni(II), Zn(II) and Mn(II) complexes 1, 2, 5 and 6, whereas with Cu(II) complexes a five-coordinate species was obtained with 4, and mixed five-and six-coordinate geometries with a doubly bridged dimetal core were observed in 3. The magnetic properties of complexes 1-4 and 6 were studied at variable temperatures and revealed weak to very weak antiferromagnetic interactions in 1, 2, 4 and 6 (J = -0.55 to -9.4 cm(-1)) and ferromagnetic coupling in 3 (J = 15.4 cm(-1)). These results are consistent with DFT calculations performed at the B3LYP/def2-TZVP(-f) level of theory. Under physiological conditions, the interaction of the dinculear complexes 1-5 with supercoiled plasmid ds-DNA did not show any pronounced nuclease activity, but Ni(II) complexes 1 and 2 revealed a strong ability to unwind the supercoiled conformation of ds-DNA. The mechanistic studies performed on the interaction of the Ni(II) complexes with DNA demonstrated the important impact of the nickel(II) ion in the unwinding process. In combination with the DNA study, the phosphatase activity of complexes 1, 3, and 5 was examined by the phosphodiester hydrolysis of bis(2,4-dinitrophenol) phosphate (BDNPP) in the pH range of 5.5-10.5 at 25 degrees C.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CA - Anorganická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/LO1305" target="_blank" >LO1305: Rozvoj centra pokročilých technologií a materiálů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Dalton Transactions (print)

ISSN

1477-9226

e-ISSN

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Svazek periodika

45

Číslo periodika v rámci svazku

32

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

18

Strana od-do

12933-12950

Kód UT WoS článku

000381478500040

EID výsledku v databázi Scopus

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