Cobalt(II) and copper(II) covalently and non-covalently dichlorido-bridged complexes of an unsymmetrical tripodal pyrazolyl-pyridyl amine ligand: Structures, magnetism and cytotoxicity

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F16%3A33161125" target="_blank" >RIV/61989592:15310/16:33161125 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S0020169316303401" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0020169316303401</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ica.2016.06.030" target="_blank" >10.1016/j.ica.2016.06.030</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Cobalt(II) and copper(II) covalently and non-covalently dichlorido-bridged complexes of an unsymmetrical tripodal pyrazolyl-pyridyl amine ligand: Structures, magnetism and cytotoxicity

Popis výsledku v původním jazyce

The reaction of a methanolic solution containing (MCl2)-Cl-II (M = Co or Cu) with bis(3,5-dimethyl-1H-pyrazol-1-yl-1-ethyl)(2-pyridylmethyl)amine (bedmpzp) in the presence of NH4PF6 afforded the dinuclear doubly bridged-dichlorido complex [Co-2(bedmpzp)(2)(mu-Cl)(2)](PF6)(2) (1) and the mononuclear [Cu(bedmpzp)Cl]PF6 (2) one. The complexes were structurally and magnetically characterized. The weak ferromagnetic exchange and the axial type of magnetic anisotropy found in 1 is associated with slow relaxation of magnetization as revealed by AC susceptibility measurements. This finding puts 1 into a class of polynuclear single-molecule magnets based on 3d metals. X-ray structure of 2 revealed mononuclear nature of the complex, forming supramolecular dimers in the solid state. The non-covalent interactions of the Cu center dot center dot center dot Cl type present in its crystal structure induced a weak antiferromagnetic exchange. The results of magnetic analysis were also supported by DFT and CASSCF/NEVPT2 calculations. The in vitro cytotoxicity of the complexes against MCF7 and HeLa human cancer cell lines were also tested. The best cytotoxicity was achieved for complex 2 on HeLa, with IC50 = 2.5(0.9) mu M.

Název v anglickém jazyce

Cobalt(II) and copper(II) covalently and non-covalently dichlorido-bridged complexes of an unsymmetrical tripodal pyrazolyl-pyridyl amine ligand: Structures, magnetism and cytotoxicity

Popis výsledku anglicky

The reaction of a methanolic solution containing (MCl2)-Cl-II (M = Co or Cu) with bis(3,5-dimethyl-1H-pyrazol-1-yl-1-ethyl)(2-pyridylmethyl)amine (bedmpzp) in the presence of NH4PF6 afforded the dinuclear doubly bridged-dichlorido complex [Co-2(bedmpzp)(2)(mu-Cl)(2)](PF6)(2) (1) and the mononuclear [Cu(bedmpzp)Cl]PF6 (2) one. The complexes were structurally and magnetically characterized. The weak ferromagnetic exchange and the axial type of magnetic anisotropy found in 1 is associated with slow relaxation of magnetization as revealed by AC susceptibility measurements. This finding puts 1 into a class of polynuclear single-molecule magnets based on 3d metals. X-ray structure of 2 revealed mononuclear nature of the complex, forming supramolecular dimers in the solid state. The non-covalent interactions of the Cu center dot center dot center dot Cl type present in its crystal structure induced a weak antiferromagnetic exchange. The results of magnetic analysis were also supported by DFT and CASSCF/NEVPT2 calculations. The in vitro cytotoxicity of the complexes against MCF7 and HeLa human cancer cell lines were also tested. The best cytotoxicity was achieved for complex 2 on HeLa, with IC50 = 2.5(0.9) mu M.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CA - Anorganická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/LO1305" target="_blank" >LO1305: Rozvoj centra pokročilých technologií a materiálů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Inorganica Chimica Acta

ISSN

0020-1693

e-ISSN

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Svazek periodika

451

Číslo periodika v rámci svazku

SEP

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

9

Strana od-do

102-110

Kód UT WoS článku

000381965300013

EID výsledku v databázi Scopus

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