Bacterial resistance to silver nanoparticles

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F19%3A73604007" target="_blank" >RIV/61989592:15310/19:73604007 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.confer.cz/nanocon/2018/135-bacterial-resistance-to-silver-nanoparticles" target="_blank" >https://www.confer.cz/nanocon/2018/135-bacterial-resistance-to-silver-nanoparticles</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Bacterial resistance to silver nanoparticles

Popis výsledku v původním jazyce

Silver nanoparticles (NPs) exhibit significant antimicrobial activity against a broad range of bacteria and fungi at concentrations ranging from a few ppm to tens of ppm that are not cytotoxic to human cells. Silver NPs also strongly enhance antibacterial activity against multiresistant, beta-lactamase and carbapenemase-producing Enterobacteriaceae when combined with antibiotics. As a result, silver NPs have already been applied in various biomedical and antimicrobial technologies and products of every-day life as an alternative to conventional antibiotics. While antibiotic resistance has been discussed extensively in the literature, the possible development of resistance to silver NPs after repeated long-term exposure has not been fully explored. We report that bacteria can develop resistance to silver NPs after prolonged exposure. The observed resistance consists in aggregation of silver NPs which consequently eliminates their antibacterial effects. The resistance mechanism can be overcome by preventing the aggregation of silver NPs via their deposition on suitable inorganic substrate such as graphene oxide.

Název v anglickém jazyce

Bacterial resistance to silver nanoparticles

Popis výsledku anglicky

Silver nanoparticles (NPs) exhibit significant antimicrobial activity against a broad range of bacteria and fungi at concentrations ranging from a few ppm to tens of ppm that are not cytotoxic to human cells. Silver NPs also strongly enhance antibacterial activity against multiresistant, beta-lactamase and carbapenemase-producing Enterobacteriaceae when combined with antibiotics. As a result, silver NPs have already been applied in various biomedical and antimicrobial technologies and products of every-day life as an alternative to conventional antibiotics. While antibiotic resistance has been discussed extensively in the literature, the possible development of resistance to silver NPs after repeated long-term exposure has not been fully explored. We report that bacteria can develop resistance to silver NPs after prolonged exposure. The observed resistance consists in aggregation of silver NPs which consequently eliminates their antibacterial effects. The resistance mechanism can be overcome by preventing the aggregation of silver NPs via their deposition on suitable inorganic substrate such as graphene oxide.

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

21001 - Nano-materials (production and properties)

Projekt

<a href="/cs/project/LO1305" target="_blank" >LO1305: Rozvoj centra pokročilých technologií a materiálů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Proceedings 10th International Conference on Nanomaterials - Research &amp; Application

ISBN

978-80-87294-89-5

ISSN

2694-930X

e-ISSN

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Počet stran výsledku

6

Strana od-do

312-317

Název nakladatele

Tanger infosystems

Místo vydání

Ostrava

Místo konání akce

Brno

Datum konání akce

17. 10. 2018

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

000513131900054