Electropolymerization of chitosan in the presence of CuNPs on the surface of a copper electrode: an advanced nanocomposite for the determination of mefenamic acid and indomethacin in human plasma samples and prevention of drug poisoning

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F20%3A73603910" target="_blank" >RIV/61989592:15310/20:73603910 - isvavai.cz</a>

Výsledek na webu

<a href="https://pubs.rsc.org/en/content/articlelanding/2020/AY/C9AY02789K#!divAbstract" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2020/AY/C9AY02789K#!divAbstract</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/c9ay02789k" target="_blank" >10.1039/c9ay02789k</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Electropolymerization of chitosan in the presence of CuNPs on the surface of a copper electrode: an advanced nanocomposite for the determination of mefenamic acid and indomethacin in human plasma samples and prevention of drug poisoning

Popis výsledku v původním jazyce

An innovative method was introduced for the electro-polymerization of chitosan on the surface of a copper electrode. Two electrochemical sensors for the detection and determination of indomethacin and mefenamic acid in human plasma samples were constructed based on copper nanoparticles (CuNPs) and poly-chitosan-modified CuNPs, respectively. The electrochemical behaviors of the CuNP-modified copper electrode (CuE) and poly-chitosan-doped CuNP-modified copper electrode (P(CS)-CuNP-CuE) were investigated using differential pulse voltammetry and cyclic voltammetry techniques. The electrochemical results show that CuNPs and P(CS)-CuNPs lead to increased oxidation peak current by the adsorption of indomethacin. According to the obtained results, we inferred that the linear range and low limit of quantification (LLOQ) were 1 nM to 10 mM and 1 nM, respectively.

Název v anglickém jazyce

Electropolymerization of chitosan in the presence of CuNPs on the surface of a copper electrode: an advanced nanocomposite for the determination of mefenamic acid and indomethacin in human plasma samples and prevention of drug poisoning

Popis výsledku anglicky

An innovative method was introduced for the electro-polymerization of chitosan on the surface of a copper electrode. Two electrochemical sensors for the detection and determination of indomethacin and mefenamic acid in human plasma samples were constructed based on copper nanoparticles (CuNPs) and poly-chitosan-modified CuNPs, respectively. The electrochemical behaviors of the CuNP-modified copper electrode (CuE) and poly-chitosan-doped CuNP-modified copper electrode (P(CS)-CuNP-CuE) were investigated using differential pulse voltammetry and cyclic voltammetry techniques. The electrochemical results show that CuNPs and P(CS)-CuNPs lead to increased oxidation peak current by the adsorption of indomethacin. According to the obtained results, we inferred that the linear range and low limit of quantification (LLOQ) were 1 nM to 10 mM and 1 nM, respectively.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10406 - Analytical chemistry

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Analytical Methods

ISSN

1759-9660

e-ISSN

—

Svazek periodika

12

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

6

Strana od-do

1212-1217

Kód UT WoS článku

000519116000004

EID výsledku v databázi Scopus

2-s2.0-85081385047