Dextrans as Permeation Markers and Carriers for Oral Transmucosal Drug Delivery

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F20%3A73604243" target="_blank" >RIV/61989592:15310/20:73604243 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/3673" target="_blank" >http://www.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/3673</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Dextrans as Permeation Markers and Carriers for Oral Transmucosal Drug Delivery

Popis výsledku v původním jazyce

Dextrans are studied as markers of oral transmucosal permeability and as possible drug carriers. The therapeutic use of dextrans is primarily limited to the intravenous route of administration. This work focuses on extending the knowledge of dextran permeation by the sublingual route. First, it is documented that non-keratinized sublingual membranes are very sensitive to heat treatment and storage conditions (more than skin membranes). Slow freezing disrupts them seriously, leading to disproportionately high permeability values, even for dextrans with a molecular weight higher than 20 kDa, which, however, may well serve as permeation markers. The dextran gyration radius reflects in vitro oral transmucosal permeability characteristics more appropriately than the pertinent molecular weight values. Macromolecular systems with a gyration radius analogous to 4 kDa dextran, possibly coupled with low molecular weight drugs, have sufficient potential for sublingual systemic drug delivery.

Název v anglickém jazyce

Dextrans as Permeation Markers and Carriers for Oral Transmucosal Drug Delivery

Popis výsledku anglicky

Dextrans are studied as markers of oral transmucosal permeability and as possible drug carriers. The therapeutic use of dextrans is primarily limited to the intravenous route of administration. This work focuses on extending the knowledge of dextran permeation by the sublingual route. First, it is documented that non-keratinized sublingual membranes are very sensitive to heat treatment and storage conditions (more than skin membranes). Slow freezing disrupts them seriously, leading to disproportionately high permeability values, even for dextrans with a molecular weight higher than 20 kDa, which, however, may well serve as permeation markers. The dextran gyration radius reflects in vitro oral transmucosal permeability characteristics more appropriately than the pertinent molecular weight values. Macromolecular systems with a gyration radius analogous to 4 kDa dextran, possibly coupled with low molecular weight drugs, have sufficient potential for sublingual systemic drug delivery.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

10403 - Physical chemistry

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

CHEMICKE LISTY

ISSN

0009-2770

e-ISSN

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Svazek periodika

114

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

7

Strana od-do

552-558

Kód UT WoS článku

000558763200007

EID výsledku v databázi Scopus

2-s2.0-85089475370