Nanofibre-based mucoadhesive film for oromucosal delivery of therapeutic nanoparticles

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Nanofibre-based mucoadhesive film for oromucosal delivery of therapeutic nanoparticles

Popis výsledku v původním jazyce

The oromucosal route of administration is an alternative route for drug-delivery and vaccine delivery. This has been used successfully for local and systemic delivery of lowmolecular-weight substances with a rapid onset of pharmacological effects, and also for drugs formulated into controlled-release systems. In addition, mucosal, especially sublingual delivery of macromolecular drug and antigen-delivery nanoparticles has become an important topic of recent research as well. In general, high permeability, a lack of enzymatic barriers, mild pH values, easy access for self-administration, and opportunities to bypass first-pass metabolism, all make the non-keratinized oral regions attractive sites for the administration of drugs and vaccines.New approaches and formulations that utilize mucoadhesives, mucus penetrating particles, or absorption enhancers can enable effective transmucosal delivery of macromolecular therapeutics, antigens and nanoparticle-based delivery systems.

Název v anglickém jazyce

Nanofibre-based mucoadhesive film for oromucosal delivery of therapeutic nanoparticles

Popis výsledku anglicky

The oromucosal route of administration is an alternative route for drug-delivery and vaccine delivery. This has been used successfully for local and systemic delivery of lowmolecular-weight substances with a rapid onset of pharmacological effects, and also for drugs formulated into controlled-release systems. In addition, mucosal, especially sublingual delivery of macromolecular drug and antigen-delivery nanoparticles has become an important topic of recent research as well. In general, high permeability, a lack of enzymatic barriers, mild pH values, easy access for self-administration, and opportunities to bypass first-pass metabolism, all make the non-keratinized oral regions attractive sites for the administration of drugs and vaccines.New approaches and formulations that utilize mucoadhesives, mucus penetrating particles, or absorption enhancers can enable effective transmucosal delivery of macromolecular therapeutics, antigens and nanoparticle-based delivery systems.

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

21001 - Nano-materials (production and properties)

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

11th International Conference Drug Delivery Systems Nanotechnology for Healthcare: Progress in Recombinant Vaccines, Molecular Adjuvants, Modern Drug Delivery Systems and Cell Therapy

ISBN

978-80-907074-6-7

ISSN

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e-ISSN

neuvedeno

Počet stran výsledku

10

Strana od-do

13-22

Název nakladatele

Nakladatelství Machovský

Místo vydání

Olomouc

Místo konání akce

Telč

Datum konání akce

5. 6. 2018

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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