Oromucosal administration of antigens and therapeutic nanoparticles using nanofibre-based mucoadhesive film

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F18%3AN0000244" target="_blank" >RIV/00027162:_____/18:N0000244 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Oromucosal administration of antigens and therapeutic nanoparticles using nanofibre-based mucoadhesive film

Popis výsledku v původním jazyce

11th International Conference, Nanotechnology for Healthcare: Progress in Recombinant Vaccines, Molecular Adjuvants and Modern Drug Delivery Systems, Telč, 5.-7.6.2018 - poster. The oromucosal route of administration is an alternative route for drug-delivery and vaccine delivery. This has been used successfully for local and systemic delivery of low-molecular-weight substances with a rapid onset of pharmacological effects, and also for drugs formulated into controlled-release systems. In addition, mucosal, especially sublingual delivery of macromolecular drug and antigen-delivery nanoparticles has become an important topic of recent research as well. In general, high permeability, a lack of enzymatic barriers, mild pH values, easy access for self-administration, and opportunities to bypass first-pass metabolism, all make the non-keratinized oral regions attractive sites for the administration of drugs and vaccines. New approaches and formulations that utilize mucoadhesives, mucus penetrating particles, or absorption enhancers can enable effective transmucosal delivery of macromolecular therapeutics, antigens and nanoparticle-based delivery systems. The presentation will focus on the combination of electrospun nanofibrous reservoir layers prepared by electrospinning, with mucoadhesive layers that together appear to represent an important new dosage platform for effective administration of antigens, adjuvants or drug-delivery and vaccination nanoparticles into oral mucosa.

Název v anglickém jazyce

Oromucosal administration of antigens and therapeutic nanoparticles using nanofibre-based mucoadhesive film

Popis výsledku anglicky

11th International Conference, Nanotechnology for Healthcare: Progress in Recombinant Vaccines, Molecular Adjuvants and Modern Drug Delivery Systems, Telč, 5.-7.6.2018 - poster. The oromucosal route of administration is an alternative route for drug-delivery and vaccine delivery. This has been used successfully for local and systemic delivery of low-molecular-weight substances with a rapid onset of pharmacological effects, and also for drugs formulated into controlled-release systems. In addition, mucosal, especially sublingual delivery of macromolecular drug and antigen-delivery nanoparticles has become an important topic of recent research as well. In general, high permeability, a lack of enzymatic barriers, mild pH values, easy access for self-administration, and opportunities to bypass first-pass metabolism, all make the non-keratinized oral regions attractive sites for the administration of drugs and vaccines. New approaches and formulations that utilize mucoadhesives, mucus penetrating particles, or absorption enhancers can enable effective transmucosal delivery of macromolecular therapeutics, antigens and nanoparticle-based delivery systems. The presentation will focus on the combination of electrospun nanofibrous reservoir layers prepared by electrospinning, with mucoadhesive layers that together appear to represent an important new dosage platform for effective administration of antigens, adjuvants or drug-delivery and vaccination nanoparticles into oral mucosa.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

<a href="/cs/project/EF15_003%2F0000495" target="_blank" >EF15_003/0000495: FIT (Farmakologie, Imunoterapie, nanoToxikologie)</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů