Nanomaterials for noninvasive sublingual vaccines

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24220%2F15%3A00002304" target="_blank" >RIV/46747885:24220/15:00002304 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.nanocon.eu/files/proceedings/23/papers/4525.pdf" target="_blank" >http://www.nanocon.eu/files/proceedings/23/papers/4525.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Nanomaterials for noninvasive sublingual vaccines

Popis výsledku v původním jazyce

New nanofibre-based mucoadhesive film was designed and prepared for oromucosal administration of nanocarriers for delivery of drug and vaccines. The mucoadhesive film is constructed from electrospun nanofibrous layer, mucoadhesive film layer and protective backing layer. While mucoadhesive film layer is responsible for tight adhesion of whole system to the oral mucosa after the application, the electrospun nanofibrous layer serves as a reservoir for therapeutic nanoparticles such as polymeric nanoparticles, liposomes, and potentially broad spectrum of nanopaticles as lipoplexes, virosomes, virus-like particles, dendrimers as well as therapeutic macromolecular drugs, antigens and allergens. Mucoadhesive film was thoroughly studied by TEM, SEM, AFM and confocal microscopy, (další techniky dopsat) and adsobtion of varoious nanoparticles like liposomes, viruses, pDNA, PLGA nanoparticles and bacterial ghosts was demonstrated. The designed system is applicable to oral mucosa, especially to sublingual and buccal tissues and enables trans/intramucosal delivery of nanoparticles. As proof of concept, the mucosal and lymph node delivery of PLGA/PEG nanoparticles and liposomes was demonstrated in porcine model. The main potential application of the system is sublingual immunisation and development of “printed vaccine technology

Název v anglickém jazyce

Nanomaterials for noninvasive sublingual vaccines

Popis výsledku anglicky

New nanofibre-based mucoadhesive film was designed and prepared for oromucosal administration of nanocarriers for delivery of drug and vaccines. The mucoadhesive film is constructed from electrospun nanofibrous layer, mucoadhesive film layer and protective backing layer. While mucoadhesive film layer is responsible for tight adhesion of whole system to the oral mucosa after the application, the electrospun nanofibrous layer serves as a reservoir for therapeutic nanoparticles such as polymeric nanoparticles, liposomes, and potentially broad spectrum of nanopaticles as lipoplexes, virosomes, virus-like particles, dendrimers as well as therapeutic macromolecular drugs, antigens and allergens. Mucoadhesive film was thoroughly studied by TEM, SEM, AFM and confocal microscopy, (další techniky dopsat) and adsobtion of varoious nanoparticles like liposomes, viruses, pDNA, PLGA nanoparticles and bacterial ghosts was demonstrated. The designed system is applicable to oral mucosa, especially to sublingual and buccal tissues and enables trans/intramucosal delivery of nanoparticles. As proof of concept, the mucosal and lymph node delivery of PLGA/PEG nanoparticles and liposomes was demonstrated in porcine model. The main potential application of the system is sublingual immunisation and development of “printed vaccine technology

Druh

O - Ostatní výsledky

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

U - Předmět řešení projektu je utajovanou skutečností podle zvláštních právních předpisů nebo je skutečností, jejíž zveřejnění by mohlo ohrozit činnost zpravodajské služby. Údaje o projektu jsou upraveny tak, aby byly zveřejnitelné