Cytotoxic dimeric half-sandwich Ru(II), Os(II) and Ir(III) complexes containing the 4,4 '-biphenyl-based bridging ligands
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F20%3A73604491" target="_blank" >RIV/61989592:15310/20:73604491 - isvavai.cz</a>
Výsledek na webu
<a href="https://onlinelibrary.wiley.com/doi/full/10.1002/aoc.5785" target="_blank" >https://onlinelibrary.wiley.com/doi/full/10.1002/aoc.5785</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/aoc.5785" target="_blank" >10.1002/aoc.5785</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Cytotoxic dimeric half-sandwich Ru(II), Os(II) and Ir(III) complexes containing the 4,4 '-biphenyl-based bridging ligands
Popis výsledku v původním jazyce
A series of dinuclear half-sandwich Ru(II), Os(II) and Ir(III) complexes [Ru-2(mu-L-n)(eta(6)-pcym)(2)Cl-2](PF6)(2) (1, 4), [Os-2(mu-L-n)(eta(6)-pcym)(2)Cl-2](PF6)(2) (2, 5) and [Ir-2(mu-L-n)(eta(5)-Cp*)(2)Cl-2](PF6)(2) (3, 6), based on 4,4 '-biphenyl-based bridging Schiff base ligands N,N '-(biphenyl-4,4 '-diyldimethylidyne)bis-2-(pyridin-2-yl)methanamine (L-1; for 1-3) and N,N '-(biphenyl-4,4 '-diyldimethylidyne)bis-2-(pyridin-2-yl)ethanamine (L-2; for 4-6) is reported; pcym = 1-methyl-4-(propan-2-yl)benzene, Cp* = pentamethylcyclopentadienyl. The complexes were characterized by relevant analytical techniques (i.e. elemental analysis, FT-IR, NMR, ESI-MS), and their in vitro cytotoxicity was assessed at six cancerous and two non-cancerous (healthy) human cell lines. Overall, complexes 4-6, containing the L-2 bridging ligand, revealed higher cytotoxicity as compared with 1-3 and, thus, they were studied in greater detail. The best-performing complex 6 exceeded at least twice the in vitro cytotoxicity of cisplatin and showed high selectivity towards the cancer cells over the normal ones, including the primary culture of human hepatocytes. In contrast to cisplatin, complexes 4-6 did not induce the cell cycle modification of the treated A2780 human ovarian carcinoma cells (studied by flow cytometry and Western blot analysis). High levels of superoxide anion were induced by complexes 4-6 at the A2780 cells. The levels of activated forms of Caspase-3 and Caspase-8 at the A2780 cells treated by Ru(II) complex 4 were comparable with cisplatin, while complexes 5 and 6 had only a minor effect on activation of these caspases.
Název v anglickém jazyce
Cytotoxic dimeric half-sandwich Ru(II), Os(II) and Ir(III) complexes containing the 4,4 '-biphenyl-based bridging ligands
Popis výsledku anglicky
A series of dinuclear half-sandwich Ru(II), Os(II) and Ir(III) complexes [Ru-2(mu-L-n)(eta(6)-pcym)(2)Cl-2](PF6)(2) (1, 4), [Os-2(mu-L-n)(eta(6)-pcym)(2)Cl-2](PF6)(2) (2, 5) and [Ir-2(mu-L-n)(eta(5)-Cp*)(2)Cl-2](PF6)(2) (3, 6), based on 4,4 '-biphenyl-based bridging Schiff base ligands N,N '-(biphenyl-4,4 '-diyldimethylidyne)bis-2-(pyridin-2-yl)methanamine (L-1; for 1-3) and N,N '-(biphenyl-4,4 '-diyldimethylidyne)bis-2-(pyridin-2-yl)ethanamine (L-2; for 4-6) is reported; pcym = 1-methyl-4-(propan-2-yl)benzene, Cp* = pentamethylcyclopentadienyl. The complexes were characterized by relevant analytical techniques (i.e. elemental analysis, FT-IR, NMR, ESI-MS), and their in vitro cytotoxicity was assessed at six cancerous and two non-cancerous (healthy) human cell lines. Overall, complexes 4-6, containing the L-2 bridging ligand, revealed higher cytotoxicity as compared with 1-3 and, thus, they were studied in greater detail. The best-performing complex 6 exceeded at least twice the in vitro cytotoxicity of cisplatin and showed high selectivity towards the cancer cells over the normal ones, including the primary culture of human hepatocytes. In contrast to cisplatin, complexes 4-6 did not induce the cell cycle modification of the treated A2780 human ovarian carcinoma cells (studied by flow cytometry and Western blot analysis). High levels of superoxide anion were induced by complexes 4-6 at the A2780 cells. The levels of activated forms of Caspase-3 and Caspase-8 at the A2780 cells treated by Ru(II) complex 4 were comparable with cisplatin, while complexes 5 and 6 had only a minor effect on activation of these caspases.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10402 - Inorganic and nuclear chemistry
Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2020
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
APPLIED ORGANOMETALLIC CHEMISTRY
ISSN
0268-2605
e-ISSN
—
Svazek periodika
34
Číslo periodika v rámci svazku
9
Stát vydavatele periodika
GB - Spojené království Velké Británie a Severního Irska
Počet stran výsledku
15
Strana od-do
"e5785-1"-"e5785-15"
Kód UT WoS článku
000533991000001
EID výsledku v databázi Scopus
2-s2.0-85084990923