A disposable electrochemical sensor based on single-walled carbon nanotubes for the determination of anticancer drug dasatinib

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F23%3A73621533" target="_blank" >RIV/61989592:15310/23:73621533 - isvavai.cz</a>

Výsledek na webu

<a href="https://link.springer.com/article/10.1007/s00706-023-03043-w" target="_blank" >https://link.springer.com/article/10.1007/s00706-023-03043-w</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00706-023-03043-w" target="_blank" >10.1007/s00706-023-03043-w</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A disposable electrochemical sensor based on single-walled carbon nanotubes for the determination of anticancer drug dasatinib

Popis výsledku v původním jazyce

Dasatinib is an anticancer drug that treats acute lymphoblastic leukemia, chronic myelogenous leukemia, and prostate cancer with several side effects. In this research, we suggest nanoparticle-modified screen-printed electrodes (SPCEs) as disposable electrochemical sensors for fast quantification of dasatinib in pharmaceutical formulations. Carbon nanotubes, single-walled carbon nanotubes (SWCNT), graphene, and graphene oxide-modified SPCEs were characterized by scanning electron microscopy. The study also recommends SWCNT-modified SPCEs as the best-performing electrode for determining dasatinib, demonstrating an excellent boosting effect on the oxidation response of dasatinib. This was accomplished using the square-wave voltammetry method. After optimization of the pH condition, pH 5.0 Britton-Robinson buffer, SWCNT-modified SPCEs demonstrated 94% recovery with optimum electro-oxidation activity. The oxidation currents exhibited linear relation with dasatinib concentration in the 0.1-100 mu M. Based on the results, a limit of detection of 0.06 mu M was obtained in the standard solution. The SWCNT-modified SPCEs have been applied to analyze dasatinib in pharmaceutical tablet samples. The demonstrated performance beats all comparable standard analytical tools and presumably may be used for general drug quantitation in pharmaceutical tablets.

Název v anglickém jazyce

A disposable electrochemical sensor based on single-walled carbon nanotubes for the determination of anticancer drug dasatinib

Popis výsledku anglicky

Dasatinib is an anticancer drug that treats acute lymphoblastic leukemia, chronic myelogenous leukemia, and prostate cancer with several side effects. In this research, we suggest nanoparticle-modified screen-printed electrodes (SPCEs) as disposable electrochemical sensors for fast quantification of dasatinib in pharmaceutical formulations. Carbon nanotubes, single-walled carbon nanotubes (SWCNT), graphene, and graphene oxide-modified SPCEs were characterized by scanning electron microscopy. The study also recommends SWCNT-modified SPCEs as the best-performing electrode for determining dasatinib, demonstrating an excellent boosting effect on the oxidation response of dasatinib. This was accomplished using the square-wave voltammetry method. After optimization of the pH condition, pH 5.0 Britton-Robinson buffer, SWCNT-modified SPCEs demonstrated 94% recovery with optimum electro-oxidation activity. The oxidation currents exhibited linear relation with dasatinib concentration in the 0.1-100 mu M. Based on the results, a limit of detection of 0.06 mu M was obtained in the standard solution. The SWCNT-modified SPCEs have been applied to analyze dasatinib in pharmaceutical tablet samples. The demonstrated performance beats all comparable standard analytical tools and presumably may be used for general drug quantitation in pharmaceutical tablets.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10406 - Analytical chemistry

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

MONATSHEFTE FUR CHEMIE

ISSN

0026-9247

e-ISSN

1434-4475

Svazek periodika

154

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

AT - Rakouská republika

Počet stran výsledku

9

Strana od-do

1061-1069

Kód UT WoS článku

000952840100001

EID výsledku v databázi Scopus

2-s2.0-85150217361