Healthy vaccinee effect: a bias not to be forgotten in observational studies on COVID‑19 vaccine effectiveness

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F24%3A73627553" target="_blank" >RIV/61989592:15310/24:73627553 - isvavai.cz</a>

Výsledek na webu

<a href="https://pamw.pl/en/node/16634/pdf" target="_blank" >https://pamw.pl/en/node/16634/pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.20452/pamw.16634" target="_blank" >10.20452/pamw.16634</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Healthy vaccinee effect: a bias not to be forgotten in observational studies on COVID‑19 vaccine effectiveness

Popis výsledku v původním jazyce

Objectives:We investigated the validity of claims of the healthy vaccinee effect (HVE) in COVID-vaccine studies by analyzing associations between all-cause mortality (ACM) and COVID-19 vaccination status.Methods:Approximately 2.2 million individual records from two Czech health insurance companies were retrospectively analyzed. Each age group was stratified according to the vaccination status (unvaccinated vs. individuals less than 4 weeks vs. more than 4 weeks from Doses 1, 2, 3, and 4 or more doses of vaccine). ACMs in these groups were computed and compared.Results: Consistently over datasets and age categories, ACM was substantially lower in the vaccinated than unvaccinated groups regardless of the presence or absence of a wave of COVID-19 deaths. Moreover, the ACMs in groups more than 4 weeks from Doses 1, 2, or 3 were consistently several times higher than in those less than 4 weeks from the respective dose. HVE appears to be the only plausible explanation for this, which is further corroborated by a created mathematical model. Conclusions: In view of the presence of HVE, the baseline difference in the frailty of vaccinated and unvaccinated populations in periods without COVID-19 must be taken into account when estimating COVID-19 vaccine effectiveness from observational data.

Název v anglickém jazyce

Healthy vaccinee effect: a bias not to be forgotten in observational studies on COVID‑19 vaccine effectiveness

Popis výsledku anglicky

Objectives:We investigated the validity of claims of the healthy vaccinee effect (HVE) in COVID-vaccine studies by analyzing associations between all-cause mortality (ACM) and COVID-19 vaccination status.Methods:Approximately 2.2 million individual records from two Czech health insurance companies were retrospectively analyzed. Each age group was stratified according to the vaccination status (unvaccinated vs. individuals less than 4 weeks vs. more than 4 weeks from Doses 1, 2, 3, and 4 or more doses of vaccine). ACMs in these groups were computed and compared.Results: Consistently over datasets and age categories, ACM was substantially lower in the vaccinated than unvaccinated groups regardless of the presence or absence of a wave of COVID-19 deaths. Moreover, the ACMs in groups more than 4 weeks from Doses 1, 2, or 3 were consistently several times higher than in those less than 4 weeks from the respective dose. HVE appears to be the only plausible explanation for this, which is further corroborated by a created mathematical model. Conclusions: In view of the presence of HVE, the baseline difference in the frailty of vaccinated and unvaccinated populations in periods without COVID-19 must be taken into account when estimating COVID-19 vaccine effectiveness from observational data.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10103 - Statistics and probability

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Polish Archives of Internal Medicine-Polskie Archiwum Medycyny Wewnetrznej

ISSN

0032-3772

e-ISSN

1897-9483

Svazek periodika

134

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

PL - Polská republika

Počet stran výsledku

2

Strana od-do

"16634-1"-"16634-2"

Kód UT WoS článku

001182539800009

EID výsledku v databázi Scopus

2-s2.0-85186742855