Lipocalin-2: vývoj, analytická charakteristika a klinické testování nové ELISA

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15510%2F08%3A00006444" target="_blank" >RIV/61989592:15510/08:00006444 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00843989:_____/08:00016007 RIV/62157124:16370/08:00002061

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Lipocalin-2: Development, analytical characterization, and clinical testing of a new ELISA

Popis výsledku v původním jazyce

Lipocalin-2 (also known as neutrophil gelatinaseassociated lipocalin [NGAL]) has been described as a promising marker of metabolic syndrome associated with infl ammation. The aim of our work was to develop an assay for the determination of lipocalin-2 inhuman serum and to investigate its levels in healthy volunteers and donors suffering from metabolic syndrome. We also conducted a pilot study on individuals with metabolic syndrome and on healthy probands and measured lipocalin-2 in these individuals. We developed and evaluated the sandwich ELISA method for the quantitative determination of human lipocalin-2 in serum samples. We measured blood pressure, waist circumference, serum cholesterol, triglycerides, HDL cholesterol, LDL cholesterol, insulin, glucose, creatinine, hs-CRP, and adiponectin and calculated the BMI and Quicki insulin sensitivity index. In the study on 153 healthy volunteers, we showed that sex and age are not determinative for lipocalin-2 serum values. Furthermore, we

Název v anglickém jazyce

Lipocalin-2: Development, analytical characterization, and clinical testing of a new ELISA

Popis výsledku anglicky

Lipocalin-2 (also known as neutrophil gelatinaseassociated lipocalin [NGAL]) has been described as a promising marker of metabolic syndrome associated with infl ammation. The aim of our work was to develop an assay for the determination of lipocalin-2 inhuman serum and to investigate its levels in healthy volunteers and donors suffering from metabolic syndrome. We also conducted a pilot study on individuals with metabolic syndrome and on healthy probands and measured lipocalin-2 in these individuals. We developed and evaluated the sandwich ELISA method for the quantitative determination of human lipocalin-2 in serum samples. We measured blood pressure, waist circumference, serum cholesterol, triglycerides, HDL cholesterol, LDL cholesterol, insulin, glucose, creatinine, hs-CRP, and adiponectin and calculated the BMI and Quicki insulin sensitivity index. In the study on 153 healthy volunteers, we showed that sex and age are not determinative for lipocalin-2 serum values. Furthermore, we

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2008

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Hormone and Metabolic Research

ISSN

0018-5043

e-ISSN

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Svazek periodika

40

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

5

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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