Gold Nanoparticle-Catalyzed Multicomponent Reactions

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15640%2F21%3A73612202" target="_blank" >RIV/61989592:15640/21:73612202 - isvavai.cz</a>

Výsledek na webu

<a href="https://pubs.acs.org/doi/10.1021/acssuschemeng.1c04361" target="_blank" >https://pubs.acs.org/doi/10.1021/acssuschemeng.1c04361</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acssuschemeng.1c04361" target="_blank" >10.1021/acssuschemeng.1c04361</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Gold Nanoparticle-Catalyzed Multicomponent Reactions

Popis výsledku v původním jazyce

Nanotechnology and nanoscience hold great promise for many multidisciplinary applications, including catalysis where gold nanoparticles (GNPs) are considered &quot;safer and environmentally benign&quot; on account of the fact that they are relatively nontoxic and efficient for pivotal applications in natural-product synthesis, organic reactions, pharmaceutical industry, and medicinal chemistry. Since the physicochemical characteristics of GNPs pertain to their shape, size, composition, and surface modification, these features contribute to the reactivity and toxicity of nanomaterials in the catalytic systems. Multicomponent reactions (MCRs) lead to expeditious synthesis of biologically active molecules and active pharmaceutical ingredients (APIs) with atom economy and high efficiency, as well as a low E-factor, and they can be performed in one-pot operations deploying three or more reactants. Thus, applications of GNPs as robust catalysts in MCRs comprise an effective synthetic route with an ideal combination for the augmentation of greener and sustainable methods. Accordingly, cutting-edge examples of gold nanoparticle-catalyzed multicomponent reactions leading to a diverse range of valuable organic molecules such as isoxazolines, propargylamines, 3,4-dihydropyrimidin-2(1H)-ones, pyrans, chromeno[2,3-d]pyrimidins, pyridines, and benzodiazepines are discussed and highlighted.

Název v anglickém jazyce

Gold Nanoparticle-Catalyzed Multicomponent Reactions

Popis výsledku anglicky

Nanotechnology and nanoscience hold great promise for many multidisciplinary applications, including catalysis where gold nanoparticles (GNPs) are considered &quot;safer and environmentally benign&quot; on account of the fact that they are relatively nontoxic and efficient for pivotal applications in natural-product synthesis, organic reactions, pharmaceutical industry, and medicinal chemistry. Since the physicochemical characteristics of GNPs pertain to their shape, size, composition, and surface modification, these features contribute to the reactivity and toxicity of nanomaterials in the catalytic systems. Multicomponent reactions (MCRs) lead to expeditious synthesis of biologically active molecules and active pharmaceutical ingredients (APIs) with atom economy and high efficiency, as well as a low E-factor, and they can be performed in one-pot operations deploying three or more reactants. Thus, applications of GNPs as robust catalysts in MCRs comprise an effective synthetic route with an ideal combination for the augmentation of greener and sustainable methods. Accordingly, cutting-edge examples of gold nanoparticle-catalyzed multicomponent reactions leading to a diverse range of valuable organic molecules such as isoxazolines, propargylamines, 3,4-dihydropyrimidin-2(1H)-ones, pyrans, chromeno[2,3-d]pyrimidins, pyridines, and benzodiazepines are discussed and highlighted.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

21001 - Nano-materials (production and properties)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ACS Sustainable Chemistry &amp; Engineering

ISSN

2168-0485

e-ISSN

—

Svazek periodika

9

Číslo periodika v rámci svazku

49

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

14

Strana od-do

"16556 "- 16569

Kód UT WoS článku

000753961000004

EID výsledku v databázi Scopus

2-s2.0-85120851034