Metallothionein - Zinc- Prostate cancer: Pathogenesis and diagnostic use

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F10%3A00166772" target="_blank" >RIV/62156489:43210/10:00166772 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Metallothionein - Zinc- Prostate cancer: Pathogenesis and diagnostic use

Popis výsledku v původním jazyce

Prostate cancer (PCa) is one of the most frequent cancer and one of the most frequent cancerrelated cause of death among men. Therefore, early diagnosis, differentiation between risky and relative benign forms and understanding of pathogenesis of diseasefor further therapeutic approaches is highly desirable. Healthy prostate is unique in zinc accumulation. Zinc is (mostly) buffered by cysteine-rich low molecular protein metallothionein (MT). In contrast, PCa has altered zinc metabolism and elevated MT.In PCa patients, MT is elevated even in serum and can therefore be used as potential tumor marker due to high specifity to PCa. This could be very desirable because of inaccuracies of current prostatic specific antigen (PSA) screening. The aims of thisstudy is (1) to analyze MT-zinc relation on cell lines: to determine zinc and MT levels in cell lines PC-3 (cancer) and PNT1A (control), (2) to find relations between MT and PSA, (3) to describe potential effects of MT and/or zinc on pros

Název v anglickém jazyce

Metallothionein - Zinc- Prostate cancer: Pathogenesis and diagnostic use

Popis výsledku anglicky

Prostate cancer (PCa) is one of the most frequent cancer and one of the most frequent cancerrelated cause of death among men. Therefore, early diagnosis, differentiation between risky and relative benign forms and understanding of pathogenesis of diseasefor further therapeutic approaches is highly desirable. Healthy prostate is unique in zinc accumulation. Zinc is (mostly) buffered by cysteine-rich low molecular protein metallothionein (MT). In contrast, PCa has altered zinc metabolism and elevated MT.In PCa patients, MT is elevated even in serum and can therefore be used as potential tumor marker due to high specifity to PCa. This could be very desirable because of inaccuracies of current prostatic specific antigen (PSA) screening. The aims of thisstudy is (1) to analyze MT-zinc relation on cell lines: to determine zinc and MT levels in cell lines PC-3 (cancer) and PNT1A (control), (2) to find relations between MT and PSA, (3) to describe potential effects of MT and/or zinc on pros

Druh

D - Stať ve sborníku

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

<a href="/cs/project/GP301%2F09%2FP436" target="_blank" >GP301/09/P436: Analýza metalothioneinu u karcinomu prostaty na úrovni DNA, RNA a proteinu.</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

MendelNet 2010 Proceedings of International Ph.D. Students Conference

ISBN

978-80-7375-453-2

ISSN

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e-ISSN

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Počet stran výsledku

7

Strana od-do

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Název nakladatele

Mendelova univerzita v Brně, Agronomická fakulta

Místo vydání

Brno

Místo konání akce

Brno

Datum konání akce

1. 1. 2000

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

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