Electrochemical study of doxorubicin interaction with different sequences of double stranded oligonucleotides, Part II

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F12%3A00182656" target="_blank" >RIV/62156489:43210/12:00182656 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11310/12:10126257 RIV/00216305:26620/12:PU95570 RIV/00216224:14310/12:00060307 RIV/00216208:11130/12:8023 RIV/00064203:_____/12:8023

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Electrochemical study of doxorubicin interaction with different sequences of double stranded oligonucleotides, Part II

Popis výsledku v původním jazyce

Interaction of low molecular weight compounds with DNA is one of general mechanisms utilized for an effective anticancer therapy. The anthracycline doxorubicin is one of the drugs that represent the compound with such effect. In our previous work [Hyneket al., Int. J. Electrochem, Sci. 7 (2012) xx] the electrochemical behaviour of doxorubicin interaction with single stranded ODN by using adsorptive transfer stripping square wave voltammetry was described. This paper is focused on the study of interaction of doxorubicin with double stranded ODNs (dsODNs) using the same technique. Here, we used four dsODNs possessing different primary structuresand observed the changes in their electrochemical behaviour after their treatment with three concentrations ofdoxorubicin for 5 hours. The changes found are discussed and differences in behaviours of individual dsODNs described and associated with their structure.

Název v anglickém jazyce

Electrochemical study of doxorubicin interaction with different sequences of double stranded oligonucleotides, Part II

Popis výsledku anglicky

Interaction of low molecular weight compounds with DNA is one of general mechanisms utilized for an effective anticancer therapy. The anthracycline doxorubicin is one of the drugs that represent the compound with such effect. In our previous work [Hyneket al., Int. J. Electrochem, Sci. 7 (2012) xx] the electrochemical behaviour of doxorubicin interaction with single stranded ODN by using adsorptive transfer stripping square wave voltammetry was described. This paper is focused on the study of interaction of doxorubicin with double stranded ODNs (dsODNs) using the same technique. Here, we used four dsODNs possessing different primary structuresand observed the changes in their electrochemical behaviour after their treatment with three concentrations ofdoxorubicin for 5 hours. The changes found are discussed and differences in behaviours of individual dsODNs described and associated with their structure.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Electrochemical Science

ISSN

1452-3981

e-ISSN

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Svazek periodika

7

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

RS - Srbská republika

Počet stran výsledku

16

Strana od-do

34-49

Kód UT WoS článku

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EID výsledku v databázi Scopus

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