Electrochemical characterization of doxorubicin interaction with DNA

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F12%3A00198451" target="_blank" >RIV/62156489:43210/12:00198451 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Electrochemical characterization of doxorubicin interaction with DNA

Popis výsledku v původním jazyce

Doxorubicin as a member of anthracycline antibiotics is one of the most widely used for the treatment of malignant tumours with the ability to interact with DNA. Electrochemistry is considered one of the most sensitive methods for studying DNA [1, 2]. The aim of the study was: i) electrochemical characterization of the interaction of doxorubicin with single and double stranded oligonucleotides, ii) investigation of the influence of different sequence on the interaction, iii) time dependence of the effect of doxorubicin and oligonucleotides. Four different variants of ODN were designed and the influence of sequence on interaction with doxorubicin was investigated. The obtained data were processed showing the correlation dependence of size change of DOXOpeak to peak size change of the peak of each ODN. This dependence was studied also in the time manner (time interaction DOXO with ODN) as 30, 150, 240 and 300 min. The value of [100, 0] represents the initial state of electrochemical ana

Název v anglickém jazyce

Electrochemical characterization of doxorubicin interaction with DNA

Popis výsledku anglicky

Doxorubicin as a member of anthracycline antibiotics is one of the most widely used for the treatment of malignant tumours with the ability to interact with DNA. Electrochemistry is considered one of the most sensitive methods for studying DNA [1, 2]. The aim of the study was: i) electrochemical characterization of the interaction of doxorubicin with single and double stranded oligonucleotides, ii) investigation of the influence of different sequence on the interaction, iii) time dependence of the effect of doxorubicin and oligonucleotides. Four different variants of ODN were designed and the influence of sequence on interaction with doxorubicin was investigated. The obtained data were processed showing the correlation dependence of size change of DOXOpeak to peak size change of the peak of each ODN. This dependence was studied also in the time manner (time interaction DOXO with ODN) as 30, 150, 240 and 300 min. The value of [100, 0] represents the initial state of electrochemical ana

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CG - Elektrochemie

OECD FORD obor

—

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Molecular Medicine

ISSN

1107-3756

e-ISSN

—

Svazek periodika

30

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GR - Řecká republika

Počet stran výsledku

1

Strana od-do

45

Kód UT WoS článku

—

EID výsledku v databázi Scopus

—