Metallothionein electrochemically determined using Brdicka reaction as a promising blood marker of head and neck malignant tumours

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F12%3A00184859" target="_blank" >RIV/62156489:43210/12:00184859 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11310/12:10126270 RIV/00216224:14110/12:00059527 RIV/00216208:11130/12:8025 RIV/00216305:26620/12:PU97469 RIV/00064203:_____/12:8025

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Metallothionein electrochemically determined using Brdicka reaction as a promising blood marker of head and neck malignant tumours

Popis výsledku v původním jazyce

There are more than half of million patients who fall ill with head and neck carcinoma per year, which 6 % of annually newly diagnosed malignant diseases in the world. Group of head and neck tumours includes tumours occurring in the upper respiratory tract and upper digestive tract. They include tumours occurring in the area of oral cavity, tumours of hard and soft palate, gingivae and tongue. However, suitable markers in the case of head and neck carcinoma have not been satisfactory identified. Metallothioneins as a group of proteins with unknown but important role in development of a tumour can be assumed as a potential marker. Therefore, electrochemical monitoring of metallothionein levels in patients suffering from primary malignant tumour in headand neck area and examination of a suitability of electrochemical detection as a technique to be used in clinical practise are the most important aims of this study. Differential pulse voltammetry Brdicka reaction was optimized (time of a

Název v anglickém jazyce

Metallothionein electrochemically determined using Brdicka reaction as a promising blood marker of head and neck malignant tumours

Popis výsledku anglicky

There are more than half of million patients who fall ill with head and neck carcinoma per year, which 6 % of annually newly diagnosed malignant diseases in the world. Group of head and neck tumours includes tumours occurring in the upper respiratory tract and upper digestive tract. They include tumours occurring in the area of oral cavity, tumours of hard and soft palate, gingivae and tongue. However, suitable markers in the case of head and neck carcinoma have not been satisfactory identified. Metallothioneins as a group of proteins with unknown but important role in development of a tumour can be assumed as a potential marker. Therefore, electrochemical monitoring of metallothionein levels in patients suffering from primary malignant tumour in headand neck area and examination of a suitability of electrochemical detection as a technique to be used in clinical practise are the most important aims of this study. Differential pulse voltammetry Brdicka reaction was optimized (time of a

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Electrochemical Science

ISSN

1452-3981

e-ISSN

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Svazek periodika

7

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

RS - Srbská republika

Počet stran výsledku

18

Strana od-do

1767-1784

Kód UT WoS článku

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EID výsledku v databázi Scopus

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