Association of PSA level with thiols content in patients with prostate carcinoma

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F12%3A00198376" target="_blank" >RIV/62156489:43210/12:00198376 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Association of PSA level with thiols content in patients with prostate carcinoma

Popis výsledku v původním jazyce

To detect prostate carcinoma, prostatic specific antigen (PSA) is mostly used. However diagnostics of this tumour disease can become more precise using other types of molecules [1]. In this study we aimed at determination of reduced (GSH) and oxidized (GSSG) glutathione and its ratio and level of metallothionein in blood of patients with prostate carcinoma. The obtained results were correlated with PSA levels determined in blood of patients. Analyses were performed in 35 patients with prostate cancer atthe age of 54 to 79 years with an average of 66 years and in 8 healthy subjects who formed the control group. PSA levels in patients ranged from 1.4 to 6.4 ng*ml-1 with an average of 2.4 ng*ml-1, GSH/GSSG from 0.6 to 6.7 with an average of 4.3 and metallothionein content ranged from 0.97 to 2.42 uM with an average of 1.91 uM. In the control group PSA values ranged from 0.06 to 0.14 ng*ml-1 with an average of 0.11 ng*ml-1, GSH/GSSG from 7.8 to 13.8 with an average of 9.4 and metallothion

Název v anglickém jazyce

Association of PSA level with thiols content in patients with prostate carcinoma

Popis výsledku anglicky

To detect prostate carcinoma, prostatic specific antigen (PSA) is mostly used. However diagnostics of this tumour disease can become more precise using other types of molecules [1]. In this study we aimed at determination of reduced (GSH) and oxidized (GSSG) glutathione and its ratio and level of metallothionein in blood of patients with prostate carcinoma. The obtained results were correlated with PSA levels determined in blood of patients. Analyses were performed in 35 patients with prostate cancer atthe age of 54 to 79 years with an average of 66 years and in 8 healthy subjects who formed the control group. PSA levels in patients ranged from 1.4 to 6.4 ng*ml-1 with an average of 2.4 ng*ml-1, GSH/GSSG from 0.6 to 6.7 with an average of 4.3 and metallothionein content ranged from 0.97 to 2.42 uM with an average of 1.91 uM. In the control group PSA values ranged from 0.06 to 0.14 ng*ml-1 with an average of 0.11 ng*ml-1, GSH/GSSG from 7.8 to 13.8 with an average of 9.4 and metallothion

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

<a href="/cs/project/GAP301%2F10%2F0356" target="_blank" >GAP301/10/0356: Studie participace specifických mechanismů poškození DNA na cytoxicitě cytostatik vůči lidským chemosensitivním a chemorestentním neuroblastomům</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Molecular Medicine

ISSN

1107-3756

e-ISSN

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Svazek periodika

30

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GR - Řecká republika

Počet stran výsledku

1

Strana od-do

47

Kód UT WoS článku

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EID výsledku v databázi Scopus

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