Detection of selected miRNAs in prostate carcinoma

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F12%3A00198409" target="_blank" >RIV/62156489:43210/12:00198409 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Detection of selected miRNAs in prostate carcinoma

Popis výsledku v původním jazyce

MicroRNAs (miRNAs) are small, phylogenetically conserved, noncoding RNAs that are estimated to regulate at least 30% of all protein encoding genes. Mature miRNAs are involved in post-transcriptional gene silencing. They arise from intergenic or intragenic (both exonic and intronic) genomic regions that are transcribed as long primary transcripts. In recent years, miRNAs have received attention as potential cancer diagnostic markers and therapeutic targets [1]. Deregulated miRNAs expressions were reported in various human cancers including prostate cancer. MiRNAs not only regulate various developmental and physiologic processes but also are involved in cancer development and can play roles as important biomarkers. The aim of this study was to determinate the expression levels of selected miRNA in the non-tumour PNT1A line in comparison with tumour lines 22Rv1, PC-3, and LNCaP. We used the TaqMan Gene Expression Assays and quantitative RT-PCR. We observed significantly higher (p<0.01) ex

Název v anglickém jazyce

Detection of selected miRNAs in prostate carcinoma

Popis výsledku anglicky

MicroRNAs (miRNAs) are small, phylogenetically conserved, noncoding RNAs that are estimated to regulate at least 30% of all protein encoding genes. Mature miRNAs are involved in post-transcriptional gene silencing. They arise from intergenic or intragenic (both exonic and intronic) genomic regions that are transcribed as long primary transcripts. In recent years, miRNAs have received attention as potential cancer diagnostic markers and therapeutic targets [1]. Deregulated miRNAs expressions were reported in various human cancers including prostate cancer. MiRNAs not only regulate various developmental and physiologic processes but also are involved in cancer development and can play roles as important biomarkers. The aim of this study was to determinate the expression levels of selected miRNA in the non-tumour PNT1A line in comparison with tumour lines 22Rv1, PC-3, and LNCaP. We used the TaqMan Gene Expression Assays and quantitative RT-PCR. We observed significantly higher (p<0.01) ex

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

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Projekt

<a href="/cs/project/GAP301%2F10%2F0356" target="_blank" >GAP301/10/0356: Studie participace specifických mechanismů poškození DNA na cytoxicitě cytostatik vůči lidským chemosensitivním a chemorestentním neuroblastomům</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Molecular Medicine

ISSN

1107-3756

e-ISSN

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Svazek periodika

30

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GR - Řecká republika

Počet stran výsledku

1

Strana od-do

46

Kód UT WoS článku

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EID výsledku v databázi Scopus

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