Quantum dots and prion proteins: Is this a new challenge for neurodegenerative diseases imaging?
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F13%3A00213508" target="_blank" >RIV/62156489:43210/13:00213508 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216305:26620/13:PU106832
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Quantum dots and prion proteins: Is this a new challenge for neurodegenerative diseases imaging?
Popis výsledku v původním jazyce
A diagnostics of infectious diseases can be done by the immunologic methods or by the amplification of nucleic acid specific to contagious agent using polymerase chain reaction. However, in transmissible spongiform encephalopathies, the infectious agent,prion protein (PrP<sup>Sc</sup>), has the same sequence of nucleic acids as a naturally occurring protein. The other issue with the diagnosing based on the PrP<sup>Sc</sup> detection is that the pathological form of prion protein is abundant only at late stages of the disease in a brain. Therefore, the diagnostics of prion protein caused diseases represent a sort of challenges as that hosts can incubate infectious prion proteins for many months or even years. Therefore, new in vivo assays for detectionof prion proteins and for diagnosis of their relation to neurodegenerative diseases are summarized. Their applicability and future prospects in this field are discussed with particular aim at using quantum dots as fluorescent labels.
Název v anglickém jazyce
Quantum dots and prion proteins: Is this a new challenge for neurodegenerative diseases imaging?
Popis výsledku anglicky
A diagnostics of infectious diseases can be done by the immunologic methods or by the amplification of nucleic acid specific to contagious agent using polymerase chain reaction. However, in transmissible spongiform encephalopathies, the infectious agent,prion protein (PrP<sup>Sc</sup>), has the same sequence of nucleic acids as a naturally occurring protein. The other issue with the diagnosing based on the PrP<sup>Sc</sup> detection is that the pathological form of prion protein is abundant only at late stages of the disease in a brain. Therefore, the diagnostics of prion protein caused diseases represent a sort of challenges as that hosts can incubate infectious prion proteins for many months or even years. Therefore, new in vivo assays for detectionof prion proteins and for diagnosis of their relation to neurodegenerative diseases are summarized. Their applicability and future prospects in this field are discussed with particular aim at using quantum dots as fluorescent labels.
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
CE - Biochemie
OECD FORD obor
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Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
O - Projekt operacniho programu
Ostatní
Rok uplatnění
2013
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Prion
ISSN
1933-6896
e-ISSN
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Svazek periodika
7
Číslo periodika v rámci svazku
5
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
10
Strana od-do
349-358
Kód UT WoS článku
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EID výsledku v databázi Scopus
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