Study of Functional Qualities of Different Types of Tailored Liposomes with Encapsulated Doxorubicin using Electrochemical and Optical Methods
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F14%3A00228468" target="_blank" >RIV/62156489:43210/14:00228468 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216305:26620/14:PU108617
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Study of Functional Qualities of Different Types of Tailored Liposomes with Encapsulated Doxorubicin using Electrochemical and Optical Methods
Popis výsledku v původním jazyce
This study points to changes in the properties of liposomes and its functional qualities in task of release of encapsulated drug doxorubicin according to the content of cholesterol in the phospholipid bilayer. The influence of sodium dodecyl sulphate (SDS) addition to liposomal variants was also evaluated too. Three variants of liposomes differing in various concentrations of cholesterol were assessed. Firstly, we focused on the toxicity of all liposomal variants to Staphyloccocus aureus and it was found that the content of cholesterol increases the IC50 values of encapsulated doxorubicin in liposome with higher concentration of cholesterol than in liposome without cholesterol even four times. Further, the new approach to comparing the influence of various liposomes on detection of encapsulated doxorubicin using the electrochemical detection with construction of differential hydrodynamic voltammograms was used. Finally, the fluorescence detection was used to confirm the release of enca
Název v anglickém jazyce
Study of Functional Qualities of Different Types of Tailored Liposomes with Encapsulated Doxorubicin using Electrochemical and Optical Methods
Popis výsledku anglicky
This study points to changes in the properties of liposomes and its functional qualities in task of release of encapsulated drug doxorubicin according to the content of cholesterol in the phospholipid bilayer. The influence of sodium dodecyl sulphate (SDS) addition to liposomal variants was also evaluated too. Three variants of liposomes differing in various concentrations of cholesterol were assessed. Firstly, we focused on the toxicity of all liposomal variants to Staphyloccocus aureus and it was found that the content of cholesterol increases the IC50 values of encapsulated doxorubicin in liposome with higher concentration of cholesterol than in liposome without cholesterol even four times. Further, the new approach to comparing the influence of various liposomes on detection of encapsulated doxorubicin using the electrochemical detection with construction of differential hydrodynamic voltammograms was used. Finally, the fluorescence detection was used to confirm the release of enca
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
CG - Elektrochemie
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: CEITEC - central european institute of technology</a><br>
Návaznosti
O - Projekt operacniho programu
Ostatní
Rok uplatnění
2014
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
International Journal of Electrochemical Science
ISSN
1452-3981
e-ISSN
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Svazek periodika
9
Číslo periodika v rámci svazku
6
Stát vydavatele periodika
RS - Srbská republika
Počet stran výsledku
15
Strana od-do
2993-3007
Kód UT WoS článku
334493300024
EID výsledku v databázi Scopus
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