NKR genes region and their genetic diversity in horses

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F14%3A00229347" target="_blank" >RIV/62156489:43210/14:00229347 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

NKR genes region and their genetic diversity in horses

Popis výsledku v původním jazyce

The genes of the immune response represent a functionally important region of vertebrate genome with demonstrated intense effect of selection. Natural killer cells (NK) are related to antigen recognition process through their highly variable receptors. The genetic variability and different expression of genes for receptors underlies functional variability of individual NK cells. As like in mouse model, the Ly49 receptors on horse NK cells are believed to bind to MHC class I molecules of target cells. The six Ly49 genes form a gene family located on horse chromosome 6 between 38 200 Kbp -- 38 500 Kbp. In this work were identified and genotyped nine microsatellites located in NK cell receptors (NKR) region, which includes genes Ly49. Using this methodological work may contribute to the estimate of its genetic diversity in this functionally important region. This methodology will be used for the association analysis of selected diseases in horses.

Název v anglickém jazyce

NKR genes region and their genetic diversity in horses

Popis výsledku anglicky

The genes of the immune response represent a functionally important region of vertebrate genome with demonstrated intense effect of selection. Natural killer cells (NK) are related to antigen recognition process through their highly variable receptors. The genetic variability and different expression of genes for receptors underlies functional variability of individual NK cells. As like in mouse model, the Ly49 receptors on horse NK cells are believed to bind to MHC class I molecules of target cells. The six Ly49 genes form a gene family located on horse chromosome 6 between 38 200 Kbp -- 38 500 Kbp. In this work were identified and genotyped nine microsatellites located in NK cell receptors (NKR) region, which includes genes Ly49. Using this methodological work may contribute to the estimate of its genetic diversity in this functionally important region. This methodology will be used for the association analysis of selected diseases in horses.

Druh

D - Stať ve sborníku

CEP obor

GJ - Choroby a škůdci zvířat, veterinární medicina

OECD FORD obor

—

Projekt

<a href="/cs/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: CEITEC - central european institute of technology</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

MendelNet 2014 - Proceedings of International PhD Students Conference

ISBN

978-80-7509-174-1

ISSN

—

e-ISSN

—

Počet stran výsledku

4

Strana od-do

490-493

Název nakladatele

Mendel University in Brno

Místo vydání

Brno, Czech Republic

Místo konání akce

Brno, Czech Republic

Datum konání akce

19. 11. 2014

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

—