Extension of the microsatellite panel for diversity studies in the equine Ly49 genes region

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F15%3A43906605" target="_blank" >RIV/62156489:43210/15:43906605 - isvavai.cz</a>

Výsledek na webu

<a href="https://mnet.mendelu.cz/mendelnet2015/mnet_2015_full.pdf" target="_blank" >https://mnet.mendelu.cz/mendelnet2015/mnet_2015_full.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Extension of the microsatellite panel for diversity studies in the equine Ly49 genes region

Popis výsledku v původním jazyce

The genetic variability and different expression of genes for receptors underlies functional variability of individual natural killer cells (NK). Like in the mouse model, the Ly49 receptors on the horse NK cells are believed to bind MHC class I moleculesof target cells. Six Ly49genes constitute a gene family located on the horse chromosome 6, between 38 200 Kbp -38 520 Kbp. Immune-response genes represent a functionally important region of the vertebrate genome subject to selection pressure. NK cells are involved in the antigen recognition process through their highly variable receptors. Our work may contribute to better estimating the genetic diversity of this functionally important region. In this work, we identified and genotyped three new polymorphic microsatellite markers that expand the original panel of microsatellite sand are located in the Ly49region.This methodology will be used for assessment genetic diversity and association analyses with selected diseases of horses.

Název v anglickém jazyce

Extension of the microsatellite panel for diversity studies in the equine Ly49 genes region

Popis výsledku anglicky

The genetic variability and different expression of genes for receptors underlies functional variability of individual natural killer cells (NK). Like in the mouse model, the Ly49 receptors on the horse NK cells are believed to bind MHC class I moleculesof target cells. Six Ly49genes constitute a gene family located on the horse chromosome 6, between 38 200 Kbp -38 520 Kbp. Immune-response genes represent a functionally important region of the vertebrate genome subject to selection pressure. NK cells are involved in the antigen recognition process through their highly variable receptors. Our work may contribute to better estimating the genetic diversity of this functionally important region. In this work, we identified and genotyped three new polymorphic microsatellite markers that expand the original panel of microsatellite sand are located in the Ly49region.This methodology will be used for assessment genetic diversity and association analyses with selected diseases of horses.

Druh

D - Stať ve sborníku

CEP obor

GJ - Choroby a škůdci zvířat, veterinární medicina

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

MendelNet 2015: Proceedings of International PhD Students Conference

ISBN

978-80-7509-363-9

ISSN

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e-ISSN

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Počet stran výsledku

4

Strana od-do

462-465

Název nakladatele

Mendelova univerzita v Brně

Místo vydání

Brno

Místo konání akce

Brno

Datum konání akce

11. 11. 2015

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

000366466100087