Electrochemical Methods for Study of Influence of Selenium Nanoparticles on Antioxidant Status of Rats
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F16%3A43909214" target="_blank" >RIV/62156489:43210/16:43909214 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216305:26620/16:PU120395
Výsledek na webu
<a href="http://dx.doi.org/10.20964/110402799" target="_blank" >http://dx.doi.org/10.20964/110402799</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.20964/110402799" target="_blank" >10.20964/110402799</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Electrochemical Methods for Study of Influence of Selenium Nanoparticles on Antioxidant Status of Rats
Popis výsledku v původním jazyce
The aim of the experiment was to determine the effect of selenium nanoparticles (SeN) and selenium nanoparticles bound with glucose (SeN-GLU) on the antioxidant status of rats. The rats were fed with two defined forms of selenium nanoparticles for ten days. The first experimental group (n=6) was dosed with SeN solution (0.06 mg of Se per kg of body weight / day). The second experimental group (n=6) was dosed with SeN-GLU (0.06 mg of Se and 0.3 mg of glucose per kg of body weight / day). In both experimental groups, the antioxidant activity was decreased in rat plasma and increased in liver, when measured using the both free radicals (FR) and Ferric Reducing Antioxidant Power (FRAP) method. In the analysis of whole blood, a significant increase of reduced glutathione (GSH) by 41% (P < 0.05) was observed in the SeN-GLU group compared with the control goup. Higher levels of GSH were also observed in the SeN group by 12%, but without any statistical significance. On the other hand, a smaller increase in oxidized glutathione (GSSG) by 22% (P < 0.05) was observed for the SeN-GLU group and an insignificant decrease by 13% was recorded for the SeN group which implies increased GSH/GSSG ratio and higher antioxidant activity for both SeN-GLU and SeN groups in the whole blood. In the assessing of GSH in erythrocytes, a linear increase was observed for each group. An increase by 14% in the SeN group and a significant increase by 19% (P < 0.05) in the SeN-GLU group of rats was recorded. The amount of GSSG was the highest in the SeN group. In the liver, decrease in both forms of glutathione was observed. The levels of zinc and copper were not significantly changed in the plasma or in the liver. From these results, it is apparent that SeN and SeN-GLU may be considered as an alternative source of selenium for improving of antioxidant status of the animal organism, which is characterized by high usability.
Název v anglickém jazyce
Electrochemical Methods for Study of Influence of Selenium Nanoparticles on Antioxidant Status of Rats
Popis výsledku anglicky
The aim of the experiment was to determine the effect of selenium nanoparticles (SeN) and selenium nanoparticles bound with glucose (SeN-GLU) on the antioxidant status of rats. The rats were fed with two defined forms of selenium nanoparticles for ten days. The first experimental group (n=6) was dosed with SeN solution (0.06 mg of Se per kg of body weight / day). The second experimental group (n=6) was dosed with SeN-GLU (0.06 mg of Se and 0.3 mg of glucose per kg of body weight / day). In both experimental groups, the antioxidant activity was decreased in rat plasma and increased in liver, when measured using the both free radicals (FR) and Ferric Reducing Antioxidant Power (FRAP) method. In the analysis of whole blood, a significant increase of reduced glutathione (GSH) by 41% (P < 0.05) was observed in the SeN-GLU group compared with the control goup. Higher levels of GSH were also observed in the SeN group by 12%, but without any statistical significance. On the other hand, a smaller increase in oxidized glutathione (GSSG) by 22% (P < 0.05) was observed for the SeN-GLU group and an insignificant decrease by 13% was recorded for the SeN group which implies increased GSH/GSSG ratio and higher antioxidant activity for both SeN-GLU and SeN groups in the whole blood. In the assessing of GSH in erythrocytes, a linear increase was observed for each group. An increase by 14% in the SeN group and a significant increase by 19% (P < 0.05) in the SeN-GLU group of rats was recorded. The amount of GSSG was the highest in the SeN group. In the liver, decrease in both forms of glutathione was observed. The levels of zinc and copper were not significantly changed in the plasma or in the liver. From these results, it is apparent that SeN and SeN-GLU may be considered as an alternative source of selenium for improving of antioxidant status of the animal organism, which is characterized by high usability.
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
GH - Výživa hospodářských zvířat
OECD FORD obor
—
Návaznosti výsledku
Projekt
<a href="/cs/project/QJ1310100" target="_blank" >QJ1310100: Vývoj a optimalizace metod stanovení biogenních aminů v návaznosti na zvýšení zdravotní bezpečnosti siláží</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2016
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
International Journal of Electrochemical Science
ISSN
1452-3981
e-ISSN
—
Svazek periodika
11
Číslo periodika v rámci svazku
4
Stát vydavatele periodika
CS - Srbsko a Černá Hora
Počet stran výsledku
26
Strana od-do
2799-2824
Kód UT WoS článku
000375393900023
EID výsledku v databázi Scopus
2-s2.0-84963526296