Electrochemical Determination of Vitamin D3 in Pharmaceutical Products by Using Boron Doped Diamond Electrode
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F20%3A43916733" target="_blank" >RIV/62156489:43210/20:43916733 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216305:26620/20:PU134897
Výsledek na webu
<a href="https://doi.org/10.1002/elan.201900532" target="_blank" >https://doi.org/10.1002/elan.201900532</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/elan.201900532" target="_blank" >10.1002/elan.201900532</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Electrochemical Determination of Vitamin D3 in Pharmaceutical Products by Using Boron Doped Diamond Electrode
Popis výsledku v původním jazyce
A sensitive square-wave voltammetry method was developed to determine cholecalciferol (vitamin D3) in pharmaceutical products at boron-doped diamond electrode as a working electrode. Vitamin D3 provided a well-defined voltammetric peak at around +1.00 V (vs. Ag/AgCl, 3.5 mol dmMINUS SIGN 3) in 0.02 mol dmMINUS SIGN 3 Britton-Robinson buffer pH 5.0 prepared in 50 % ethanol. The influence of various factors such as type and pH of the supporting electrolyte, scan rate and square-wave parameters were studied and optimized. Under optimum conditions, the oxidation peak current increased linearly with the concentration of vitamin D3 over the range of 2 to 200 μmol dmMINUS SIGN 3. The calculated limit of detection and limit of quantitation were 0.17 μmol dmMINUS SIGN 3 and 0.51 μmol dmMINUS SIGN 3, respectively. The boron-doped diamond electrode exhibited specific recognition capability for cholecalciferol amongst possible interferences, and the determination of vitamin D3 was possible in samples such as commercial pharmaceutical products without complicated sample pretreatments.
Název v anglickém jazyce
Electrochemical Determination of Vitamin D3 in Pharmaceutical Products by Using Boron Doped Diamond Electrode
Popis výsledku anglicky
A sensitive square-wave voltammetry method was developed to determine cholecalciferol (vitamin D3) in pharmaceutical products at boron-doped diamond electrode as a working electrode. Vitamin D3 provided a well-defined voltammetric peak at around +1.00 V (vs. Ag/AgCl, 3.5 mol dmMINUS SIGN 3) in 0.02 mol dmMINUS SIGN 3 Britton-Robinson buffer pH 5.0 prepared in 50 % ethanol. The influence of various factors such as type and pH of the supporting electrolyte, scan rate and square-wave parameters were studied and optimized. Under optimum conditions, the oxidation peak current increased linearly with the concentration of vitamin D3 over the range of 2 to 200 μmol dmMINUS SIGN 3. The calculated limit of detection and limit of quantitation were 0.17 μmol dmMINUS SIGN 3 and 0.51 μmol dmMINUS SIGN 3, respectively. The boron-doped diamond electrode exhibited specific recognition capability for cholecalciferol amongst possible interferences, and the determination of vitamin D3 was possible in samples such as commercial pharmaceutical products without complicated sample pretreatments.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10406 - Analytical chemistry
Návaznosti výsledku
Projekt
<a href="/cs/project/LQ1601" target="_blank" >LQ1601: CEITEC 2020</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2020
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Electroanalysis
ISSN
1040-0397
e-ISSN
—
Svazek periodika
32
Číslo periodika v rámci svazku
4
Stát vydavatele periodika
DE - Spolková republika Německo
Počet stran výsledku
8
Strana od-do
741-748
Kód UT WoS článku
000495749900001
EID výsledku v databázi Scopus
2-s2.0-85075018242