Effects of diclofenac and ibuprofen on fish embryos

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F20%3A43919558" target="_blank" >RIV/62156489:43210/20:43919558 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62157124:16270/20:43879752

Výsledek na webu

<a href="https://mnet.mendelu.cz/mendelnet2020/mnet_2020_full.pdf" target="_blank" >https://mnet.mendelu.cz/mendelnet2020/mnet_2020_full.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Effects of diclofenac and ibuprofen on fish embryos

Popis výsledku v původním jazyce

Contamination of aquatic environment results in negative effects on both human and aquatic biota. Diclofenac and ibuprofen are commonly used pharmacologically active substances, which are found in aquatic environment. Occurrence of their residues in the aquatic environment is caused by constantly increasing consumption, discharge in wastewater and its imperfect purification in wastewater treatment plants. The aim of this study was to assess the impact of diclofenac and ibuprofen residues on embryonic stages of zebrafish (Danio rerio). The study was performed according to the acute toxicity test on zebrafish embryos guideline no. 236. Six different concentrations of diclofenac and ibuprofen were tested. Lethal and various sublethal effects of diclofenac and ibuprofen were observed at concentrations ranging from 2 000 μg/l to 20 000 μg/l. The most frequently negative effect was observed on the cardiovascular system, where heart edema of embryos occurred. Moreover, the results suggest negative effects on hatching. For example in the end of the experiment at the highest tested concentration of ibuprofen was hatched only 37.14% embryos. Our study showed that the non-steroidal anti-inflammatory drugs (NSAIDs) diclofenac and ibuprofen have a negative effect on the development of fish embryos.

Název v anglickém jazyce

Effects of diclofenac and ibuprofen on fish embryos

Popis výsledku anglicky

Contamination of aquatic environment results in negative effects on both human and aquatic biota. Diclofenac and ibuprofen are commonly used pharmacologically active substances, which are found in aquatic environment. Occurrence of their residues in the aquatic environment is caused by constantly increasing consumption, discharge in wastewater and its imperfect purification in wastewater treatment plants. The aim of this study was to assess the impact of diclofenac and ibuprofen residues on embryonic stages of zebrafish (Danio rerio). The study was performed according to the acute toxicity test on zebrafish embryos guideline no. 236. Six different concentrations of diclofenac and ibuprofen were tested. Lethal and various sublethal effects of diclofenac and ibuprofen were observed at concentrations ranging from 2 000 μg/l to 20 000 μg/l. The most frequently negative effect was observed on the cardiovascular system, where heart edema of embryos occurred. Moreover, the results suggest negative effects on hatching. For example in the end of the experiment at the highest tested concentration of ibuprofen was hatched only 37.14% embryos. Our study showed that the non-steroidal anti-inflammatory drugs (NSAIDs) diclofenac and ibuprofen have a negative effect on the development of fish embryos.

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

10511 - Environmental sciences (social aspects to be 5.7)

Projekt

<a href="/cs/project/EF16_019%2F0000869" target="_blank" >EF16_019/0000869: Udržitelná produkce zdravých ryb v různých akvakulturních systémech - PROFISH</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

MendelNet 2020: Proceedings of International PhD Students Conference

ISBN

978-80-7509-765-1

ISSN

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e-ISSN

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Počet stran výsledku

4

Strana od-do

195-198

Název nakladatele

Mendelova univerzita v Brně

Místo vydání

Brno

Místo konání akce

Brno

Datum konání akce

11. 11. 2020

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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