Study of selected signaling pathways genes that play an important role in bone metabolism in laying hens

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F20%3A43919586" target="_blank" >RIV/62156489:43210/20:43919586 - isvavai.cz</a>

Výsledek na webu

<a href="https://mnet.mendelu.cz/mendelnet2020/mnet_2020_full.pdf" target="_blank" >https://mnet.mendelu.cz/mendelnet2020/mnet_2020_full.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Study of selected signaling pathways genes that play an important role in bone metabolism in laying hens

Popis výsledku v původním jazyce

Due to the balanced activity of osteoclasts, the bone-reabsorbing cells, and osteoblasts, the bone-forming cells, bone remodeling is lifelong process, which can be influenced by number of factors. The key role in the control of osteoclastogenesis and osteoblastogenesis play signaling pathways. This work was primary focused on detection of single nucleotide polymorphisms in selected genes that are part of those signaling pathways that regulates skeletal development and homeostasis. The study of these genes is of great value for skeletal health and diseases in laying hens. The polymorphisms of five genes (WISP1, SOST, TNFSF11, TNFRSF11A and TNFRSF11B) was studied in order to survey their relationship with parameters of bones in hens of ISA Brown hybrids (bone breaking strength, length, width and bone mass). PCR and sequencing were used to determine the polymorphisms and each marker were tested in sixteen samples. No polymorphisms were found in selected gene regions in the experimental group of animals, which would show associations with the observed bone parameters of laying hens.

Název v anglickém jazyce

Study of selected signaling pathways genes that play an important role in bone metabolism in laying hens

Popis výsledku anglicky

Due to the balanced activity of osteoclasts, the bone-reabsorbing cells, and osteoblasts, the bone-forming cells, bone remodeling is lifelong process, which can be influenced by number of factors. The key role in the control of osteoclastogenesis and osteoblastogenesis play signaling pathways. This work was primary focused on detection of single nucleotide polymorphisms in selected genes that are part of those signaling pathways that regulates skeletal development and homeostasis. The study of these genes is of great value for skeletal health and diseases in laying hens. The polymorphisms of five genes (WISP1, SOST, TNFSF11, TNFRSF11A and TNFRSF11B) was studied in order to survey their relationship with parameters of bones in hens of ISA Brown hybrids (bone breaking strength, length, width and bone mass). PCR and sequencing were used to determine the polymorphisms and each marker were tested in sixteen samples. No polymorphisms were found in selected gene regions in the experimental group of animals, which would show associations with the observed bone parameters of laying hens.

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

40203 - Husbandry

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

MendelNet 2020: Proceedings of International PhD Students Conference

ISBN

978-80-7509-765-1

ISSN

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e-ISSN

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Počet stran výsledku

6

Strana od-do

424-429

Název nakladatele

Mendelova univerzita v Brně

Místo vydání

Brno

Místo konání akce

Brno

Datum konání akce

11. 11. 2020

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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