Synthesis of poly(lactic-co-glycolic) acid nanoparticles with incorporated fish oil

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F20%3A43919612" target="_blank" >RIV/62156489:43210/20:43919612 - isvavai.cz</a>

Výsledek na webu

<a href="https://mnet.mendelu.cz/mendelnet2020/mnet_2020_full.pdf" target="_blank" >https://mnet.mendelu.cz/mendelnet2020/mnet_2020_full.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Synthesis of poly(lactic-co-glycolic) acid nanoparticles with incorporated fish oil

Popis výsledku v původním jazyce

Wound healing remains one of the most common and economically demanding health problems in the world. Omega-3 polyunsaturated fatty acids (present in fish oil) are valued for their antiinflammatory property, which is significant in wound healing process. The main aim of this experiment was to develop organic nanoparticles (NPs) made from PLGA poly(lactic-co-glycolic acid) with incorporated fish oil (FO). The PLGA NPs with entrapped fish oil PLGA(FO) NPs synthesized by emulsion evaporation measured 233.3 nm in diameter. Value of PDI was evaluated as 0.351 a.u indicating a polydisperse sample, and the particles were very negatively charged, with a zeta potential of -68.1 mV. Particles were spherical as confirmed by TEM. The initial loading capacity was 22.4 g of FO/mg powder. The entrapment efficiency (EE %) was 22.47 %. The ability of nanodelivered FO on wound healing will be evaluated next.

Název v anglickém jazyce

Synthesis of poly(lactic-co-glycolic) acid nanoparticles with incorporated fish oil

Popis výsledku anglicky

Wound healing remains one of the most common and economically demanding health problems in the world. Omega-3 polyunsaturated fatty acids (present in fish oil) are valued for their antiinflammatory property, which is significant in wound healing process. The main aim of this experiment was to develop organic nanoparticles (NPs) made from PLGA poly(lactic-co-glycolic acid) with incorporated fish oil (FO). The PLGA NPs with entrapped fish oil PLGA(FO) NPs synthesized by emulsion evaporation measured 233.3 nm in diameter. Value of PDI was evaluated as 0.351 a.u indicating a polydisperse sample, and the particles were very negatively charged, with a zeta potential of -68.1 mV. Particles were spherical as confirmed by TEM. The initial loading capacity was 22.4 g of FO/mg powder. The entrapment efficiency (EE %) was 22.47 %. The ability of nanodelivered FO on wound healing will be evaluated next.

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

40500 - Other agricultural sciences

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

MendelNet 2020: Proceedings of International PhD Students Conference

ISBN

978-80-7509-765-1

ISSN

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e-ISSN

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Počet stran výsledku

5

Strana od-do

557-561

Název nakladatele

Mendelova univerzita v Brně

Místo vydání

Brno

Místo konání akce

Brno

Datum konání akce

11. 11. 2020

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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