Poly(lactic-co-glycolic) acid nanoparticles as a delivery system for fish oil in wound healing
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F22%3A43921709" target="_blank" >RIV/62156489:43210/22:43921709 - isvavai.cz</a>
Výsledek na webu
<a href="https://doi.org/10.2754/avb202291030285" target="_blank" >https://doi.org/10.2754/avb202291030285</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2754/avb202291030285" target="_blank" >10.2754/avb202291030285</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Poly(lactic-co-glycolic) acid nanoparticles as a delivery system for fish oil in wound healing
Popis výsledku v původním jazyce
The objective of the study was to design, synthetize and characterize poly(lactic-co-glycolic) acid (PLGA) nanoparticles (NPs) with entrapped fish oil (FO) for possible application in a cutaneous wound healing. Morphology of NPs was evaluated by transmission electron microscopy. Antimicrobial characteristics were tested using the disk diffusion method and plate count method, and cytotoxicity was evaluated by the MTT assay. Fish oil (y) was released from PLGA NPs within the time interval (x) of 96 h according to equation y = 6.2 + 0.914x. PLGA-FO NPs did not affect growth of Staphylococcus aureus or methicillin-resistant S. aureus (MRSA) strains. No cytotoxic effect of the tested NPs on the keratinocyte cell line was observed for concentration of 1 µg/ml. PLGA-FO NPs represent an interesting alternative for wound healing due to an excellent biocompatibility and unique release profile of FO, despite their lack of antimicrobial efficiency.
Název v anglickém jazyce
Poly(lactic-co-glycolic) acid nanoparticles as a delivery system for fish oil in wound healing
Popis výsledku anglicky
The objective of the study was to design, synthetize and characterize poly(lactic-co-glycolic) acid (PLGA) nanoparticles (NPs) with entrapped fish oil (FO) for possible application in a cutaneous wound healing. Morphology of NPs was evaluated by transmission electron microscopy. Antimicrobial characteristics were tested using the disk diffusion method and plate count method, and cytotoxicity was evaluated by the MTT assay. Fish oil (y) was released from PLGA NPs within the time interval (x) of 96 h according to equation y = 6.2 + 0.914x. PLGA-FO NPs did not affect growth of Staphylococcus aureus or methicillin-resistant S. aureus (MRSA) strains. No cytotoxic effect of the tested NPs on the keratinocyte cell line was observed for concentration of 1 µg/ml. PLGA-FO NPs represent an interesting alternative for wound healing due to an excellent biocompatibility and unique release profile of FO, despite their lack of antimicrobial efficiency.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30404 - Biomaterials (as related to medical implants, devices, sensors)
Návaznosti výsledku
Projekt
—
Návaznosti
S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2022
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Acta Veterinaria Brno
ISSN
0001-7213
e-ISSN
1801-7576
Svazek periodika
91
Číslo periodika v rámci svazku
3
Stát vydavatele periodika
CZ - Česká republika
Počet stran výsledku
7
Strana od-do
285-291
Kód UT WoS článku
000834835300009
EID výsledku v databázi Scopus
2-s2.0-85134492346