Palladium-loaded PLGA-chitosan NPs as efficient catalysts for bioorthogonal chemistry

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F20%3A43919616" target="_blank" >RIV/62156489:43210/20:43919616 - isvavai.cz</a>

Výsledek na webu

<a href="https://mnet.mendelu.cz/mendelnet2020/mnet_2020_full.pdf" target="_blank" >https://mnet.mendelu.cz/mendelnet2020/mnet_2020_full.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Palladium-loaded PLGA-chitosan NPs as efficient catalysts for bioorthogonal chemistry

Popis výsledku v původním jazyce

Bioorthogonal chemistry offers a wide range of reactions, which can be performed in the intracellular platform. Among the wide range of uses, bioorthogonal reactions can be employed for the controlled pro-drug activation in situ. Palladium compounds can be exploited as activation agents in the bioorthogonal reactions. However, their properties such as toxicity, poor cellular uptake and inactivation by biogenic thiols hinder their catalytic activity on the cellular level. In our study, we have prepared polymeric palladium-loaded poly(D,L-lactide-co-glycolide) (PLGA)-chitosan nanoparticles (NPs). The coating of these two polymers with chitosan has ensured cellular uptake and the gradual release of palladium compounds inside the cell. Their catalytic activity was demonstrated by the conversion of a fluorescent probe made of chemically modified 8-hydroxypyrene- 1,3,6-trisulfonic acid trisodium salt propargyl ether (HPTS-PE).

Název v anglickém jazyce

Palladium-loaded PLGA-chitosan NPs as efficient catalysts for bioorthogonal chemistry

Popis výsledku anglicky

Bioorthogonal chemistry offers a wide range of reactions, which can be performed in the intracellular platform. Among the wide range of uses, bioorthogonal reactions can be employed for the controlled pro-drug activation in situ. Palladium compounds can be exploited as activation agents in the bioorthogonal reactions. However, their properties such as toxicity, poor cellular uptake and inactivation by biogenic thiols hinder their catalytic activity on the cellular level. In our study, we have prepared polymeric palladium-loaded poly(D,L-lactide-co-glycolide) (PLGA)-chitosan nanoparticles (NPs). The coating of these two polymers with chitosan has ensured cellular uptake and the gradual release of palladium compounds inside the cell. Their catalytic activity was demonstrated by the conversion of a fluorescent probe made of chemically modified 8-hydroxypyrene- 1,3,6-trisulfonic acid trisodium salt propargyl ether (HPTS-PE).

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

MendelNet 2020: Proceedings of International PhD Students Conference

ISBN

978-80-7509-765-1

ISSN

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e-ISSN

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Počet stran výsledku

6

Strana od-do

572-577

Název nakladatele

Mendelova univerzita v Brně

Místo vydání

Brno

Místo konání akce

Brno

Datum konání akce

11. 11. 2020

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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