Orally Administrable H2S-Scavenging Metal-Organic Framework Prepared by Co-Flow Microfluidics for Comprehensive Restoration of Intestinal Milieu

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F23%3A43922910" target="_blank" >RIV/62156489:43210/23:43922910 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1002/adma.202210047" target="_blank" >https://doi.org/10.1002/adma.202210047</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/adma.202210047" target="_blank" >10.1002/adma.202210047</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Orally Administrable H2S-Scavenging Metal-Organic Framework Prepared by Co-Flow Microfluidics for Comprehensive Restoration of Intestinal Milieu

Popis výsledku v původním jazyce

Intestinal milieu disorders are strongly related to the occurrence of inflammatory bowel diseases (IBDs), which results from mucosa destruction, epithelium disruption and tight junction (TJ) proteins loss. Excess of H2S in the intestinal milieu produced by sulfate-reducing bacteria metabolism contributes to IBDs development via epithelial barrier breakdown. Conventional interventions, such as surgery and anti-inflammatory medications, are considered not completely effective because of frequent recurrence and other complications. Herein, a novel oral delivery system, a hydroxypropyl methylcellulose acetate succinate (HPMCAS)-based polymer-coated Zr-based metal-organic framework (UiO-66) with a Cux-rhodamine B (CR) probe (hereinafter referred to as HUR), was produced via co-flow microfluidic assistance with ability to reduce H2S levels, thus restoring the intestinal lumen milieu. HPMCAS serves as an enteric coating that exposes UiO-66@CR at the pH of the intestine but not the acidic pH of the stomach. The synthesized HUR exhibits notable therapeutic efficacy, including mucosa recovery, epithelium integrity restoration and TJ proteins up-regulation via H2S scavenging to protect against intestinal barrier damage and microbiome dysbiosis. Thus, HUR has been verified to be a promising theranostic platform able to decrease the H2S content for intestinal milieu disorder treatment. The presented study therefore opens the door for further exploitation for IBDs therapy.

Název v anglickém jazyce

Orally Administrable H2S-Scavenging Metal-Organic Framework Prepared by Co-Flow Microfluidics for Comprehensive Restoration of Intestinal Milieu

Popis výsledku anglicky

Intestinal milieu disorders are strongly related to the occurrence of inflammatory bowel diseases (IBDs), which results from mucosa destruction, epithelium disruption and tight junction (TJ) proteins loss. Excess of H2S in the intestinal milieu produced by sulfate-reducing bacteria metabolism contributes to IBDs development via epithelial barrier breakdown. Conventional interventions, such as surgery and anti-inflammatory medications, are considered not completely effective because of frequent recurrence and other complications. Herein, a novel oral delivery system, a hydroxypropyl methylcellulose acetate succinate (HPMCAS)-based polymer-coated Zr-based metal-organic framework (UiO-66) with a Cux-rhodamine B (CR) probe (hereinafter referred to as HUR), was produced via co-flow microfluidic assistance with ability to reduce H2S levels, thus restoring the intestinal lumen milieu. HPMCAS serves as an enteric coating that exposes UiO-66@CR at the pH of the intestine but not the acidic pH of the stomach. The synthesized HUR exhibits notable therapeutic efficacy, including mucosa recovery, epithelium integrity restoration and TJ proteins up-regulation via H2S scavenging to protect against intestinal barrier damage and microbiome dysbiosis. Thus, HUR has been verified to be a promising theranostic platform able to decrease the H2S content for intestinal milieu disorder treatment. The presented study therefore opens the door for further exploitation for IBDs therapy.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

21001 - Nano-materials (production and properties)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Advanced Materials

ISSN

0935-9648

e-ISSN

1521-4095

Svazek periodika

35

Číslo periodika v rámci svazku

14

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

16

Strana od-do

2210047

Kód UT WoS článku

000934601800001

EID výsledku v databázi Scopus

2-s2.0-85148460346