PtNi nano trilobal-based nanostructure with magnetocaloric oscillation and catalytic effects for pyroptosis-triggered tumor immunotherapy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F23%3A43923057" target="_blank" >RIV/62156489:43210/23:43923057 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1016/j.nantod.2023.101769" target="_blank" >https://doi.org/10.1016/j.nantod.2023.101769</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.nantod.2023.101769" target="_blank" >10.1016/j.nantod.2023.101769</a>

Jazyk výsledku

angličtina

Název v původním jazyce

PtNi nano trilobal-based nanostructure with magnetocaloric oscillation and catalytic effects for pyroptosis-triggered tumor immunotherapy

Popis výsledku v původním jazyce

Pyroptosis, a unique form of programmed cell death, has been verified to be linked to inflammatory diseases and malignant tumors. Although great achievements have been made in pyroptosis research, several gaps, such as innate drug resistance and severe toxicity, hinder the development of pyroptosis inducers for biomedical applications. Thus, in this study, we designed a polyethylene glycol (PEG)ylated platinum-nickel (PtNi) bimetallic &quot;trilobal&quot;-shaped nanostructure (PPTNS) for effective pyroptosis-triggered tumor immunotherapy through a nanozyme catalytic and magnetocaloric oscillation dual strategy. Upon application of an alternating magnetic field, hyperthermia and mechanical oscillation of the specific sharp angles of PPTNS promoted damage-associated molecular pattern recognition, thereby activating the caspase-1-NLRP3-GSDMD pathway to increase cytokine recruitment. Furthermore, the high specific surface area and intrinsic nanozyme activities of PPTNS efficiently generated reactive oxygen species as the pathogen-associated molecular pattern, thus stimulating pattern recognition receptors to accelerate the oligomerization of the NOD-like receptor NLRP3. By this dual strategy, pyroptosis was triggered to perforate the cell membrane, resulting in cell rupture and cytokine release. After two weeks of treatment, the sizes of the breast tumors were significantly reduced without noticeable long-term toxicity in vivo. This strategy provides a magnetic-responsive platform for proptosis-triggered immunotherapy, which offers promising prospects for the highly efficient treatment of malignant tumors.

Název v anglickém jazyce

PtNi nano trilobal-based nanostructure with magnetocaloric oscillation and catalytic effects for pyroptosis-triggered tumor immunotherapy

Popis výsledku anglicky

Pyroptosis, a unique form of programmed cell death, has been verified to be linked to inflammatory diseases and malignant tumors. Although great achievements have been made in pyroptosis research, several gaps, such as innate drug resistance and severe toxicity, hinder the development of pyroptosis inducers for biomedical applications. Thus, in this study, we designed a polyethylene glycol (PEG)ylated platinum-nickel (PtNi) bimetallic &quot;trilobal&quot;-shaped nanostructure (PPTNS) for effective pyroptosis-triggered tumor immunotherapy through a nanozyme catalytic and magnetocaloric oscillation dual strategy. Upon application of an alternating magnetic field, hyperthermia and mechanical oscillation of the specific sharp angles of PPTNS promoted damage-associated molecular pattern recognition, thereby activating the caspase-1-NLRP3-GSDMD pathway to increase cytokine recruitment. Furthermore, the high specific surface area and intrinsic nanozyme activities of PPTNS efficiently generated reactive oxygen species as the pathogen-associated molecular pattern, thus stimulating pattern recognition receptors to accelerate the oligomerization of the NOD-like receptor NLRP3. By this dual strategy, pyroptosis was triggered to perforate the cell membrane, resulting in cell rupture and cytokine release. After two weeks of treatment, the sizes of the breast tumors were significantly reduced without noticeable long-term toxicity in vivo. This strategy provides a magnetic-responsive platform for proptosis-triggered immunotherapy, which offers promising prospects for the highly efficient treatment of malignant tumors.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

21001 - Nano-materials (production and properties)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nano Today

ISSN

1748-0132

e-ISSN

1878-044X

Svazek periodika

49

Číslo periodika v rámci svazku

April

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

19

Strana od-do

101769

Kód UT WoS článku

000943164000001

EID výsledku v databázi Scopus

2-s2.0-85147857479