Magnetocaloric-Responsive Hydrogel Nanoarchitectonics for Pyroptosis-Relay-Immunotherapy to Suppress Post-Operation Tumor Recurrence and Metastasis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F24%3A43924770" target="_blank" >RIV/62156489:43210/24:43924770 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1002/adfm.202314194" target="_blank" >https://doi.org/10.1002/adfm.202314194</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/adfm.202314194" target="_blank" >10.1002/adfm.202314194</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Magnetocaloric-Responsive Hydrogel Nanoarchitectonics for Pyroptosis-Relay-Immunotherapy to Suppress Post-Operation Tumor Recurrence and Metastasis

Popis výsledku v původním jazyce

Although a widely used option in contemporary anticancer treatment, surgery still causes serious issues, including post-operation recurrence and the development of metastases. Immunotherapy, often following surgical resection of a tumor, has demonstrated benefits in improving the therapeutical outcomes of surgery. However, antigen generation and presentation play an essential role in reversing limited T-cell responses or immunological resistance. Thus, a gelatin-tannic acid gel (GelTA) crosslinked bimetallic (Zn0.35Fe0.65) magnetocaloric-responsive hydrogels (GelTAMNPs) are developed to mediate pyroptosis-relay-immunotherapy for suppressing post-operation tumor recurrence and metastasis. After surgical resection of tumor, GelTAMNPs generate hyperthermia inducible by alternating magnetic field and release ions (Fe3+, Fe2+, and Zn2+), reinforcing pyroptosis. Subsequently, the cell contents and cytokines released due to pyroptosis act as a &quot;relay baton&quot; passed from the tumor to the lymph nodes, leading to an enhanced systemic immune response. Combined with the PD-1 immune checkpoint blockade, the recurrence and metastasis are significantly suppressed. An in vivo preclinical study on B16F10 tumor-bearing mice demonstrates a long-lasting immunological activation due to post-surgical administration of GelTAMNPs. Altogether, the presented hydrogel exhibits a potential high magnetic sensitive pyroptosis-relay-immunotherapeutic platform for postoperative adjuvant treatment.

Název v anglickém jazyce

Magnetocaloric-Responsive Hydrogel Nanoarchitectonics for Pyroptosis-Relay-Immunotherapy to Suppress Post-Operation Tumor Recurrence and Metastasis

Popis výsledku anglicky

Although a widely used option in contemporary anticancer treatment, surgery still causes serious issues, including post-operation recurrence and the development of metastases. Immunotherapy, often following surgical resection of a tumor, has demonstrated benefits in improving the therapeutical outcomes of surgery. However, antigen generation and presentation play an essential role in reversing limited T-cell responses or immunological resistance. Thus, a gelatin-tannic acid gel (GelTA) crosslinked bimetallic (Zn0.35Fe0.65) magnetocaloric-responsive hydrogels (GelTAMNPs) are developed to mediate pyroptosis-relay-immunotherapy for suppressing post-operation tumor recurrence and metastasis. After surgical resection of tumor, GelTAMNPs generate hyperthermia inducible by alternating magnetic field and release ions (Fe3+, Fe2+, and Zn2+), reinforcing pyroptosis. Subsequently, the cell contents and cytokines released due to pyroptosis act as a &quot;relay baton&quot; passed from the tumor to the lymph nodes, leading to an enhanced systemic immune response. Combined with the PD-1 immune checkpoint blockade, the recurrence and metastasis are significantly suppressed. An in vivo preclinical study on B16F10 tumor-bearing mice demonstrates a long-lasting immunological activation due to post-surgical administration of GelTAMNPs. Altogether, the presented hydrogel exhibits a potential high magnetic sensitive pyroptosis-relay-immunotherapeutic platform for postoperative adjuvant treatment.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10404 - Polymer science

Projekt

<a href="/cs/project/GM23-04740M" target="_blank" >GM23-04740M: Hybridní biokompatibilní nanokatalyzátory pro extracelulární bioorthogonální aktivaci proléčiv</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Advanced Functional Materials

ISSN

1616-301X

e-ISSN

1616-3028

Svazek periodika

34

Číslo periodika v rámci svazku

22

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

17

Strana od-do

2314194

Kód UT WoS článku

001157846900001

EID výsledku v databázi Scopus

2-s2.0-85184189868