Synergistic anti-bacterial effects of green synthesized Zinc oxide nanoparticles with levofloxacin
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F23%3A43924002" target="_blank" >RIV/62156489:43210/23:43924002 - isvavai.cz</a>
Výsledek na webu
<a href="https://doi.org/10.1016/j.jksus.2023.102905" target="_blank" >https://doi.org/10.1016/j.jksus.2023.102905</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jksus.2023.102905" target="_blank" >10.1016/j.jksus.2023.102905</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Synergistic anti-bacterial effects of green synthesized Zinc oxide nanoparticles with levofloxacin
Popis výsledku v původním jazyce
Nowadays, the emergence of drug resistance was a major problem due to the limited bioavailability and unintended toxicity of antibiotics because of non-specific targeting leading to difficulty to eradicate pathogenic infections. Zinc oxide nanoparticles gain much attention as nanocarriers, due to their non-toxic, eco-friendly, and economical cost, to treat severe pathogenic infections. The purpose of this research was to produce and analyze zinc oxide nanoparticles (ZnONPs) functions using a green synthesis process to evaluate its anti-bacterial and biofilm inhibitory activities against gram-positive and -negative microorganisms. ZnONPs were formed via a green synthetic approach using a seed extract of soybean (Glycine max) and nanoparticles characterization was done using FESEM, X-ray diffraction, UV-VIS spectroscopy, and EDAX. The anti-bacterial and biofilm inhibitory activities of ZnONPs, levofloxacin, and levofloxacin-loaded ZnONPs were determined using agar disc diffusion assay and microtiter plate assay, respectively. Levofloaxcin-loaded ZnONPs showed more potent and statistically significant antibacterial activity than ZnONPs alone against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Enterococcus faecalis. The bacterial inhibition zone of levofloxacin-loaded ZnONPs at 80 µg/ml concentrations was higher in comparison to the standard levofloxacin and ZnONPs alone which showed levofloxacin-loaded ZnONPs possess effective antibacterial activity that prevent the growth of diverse microorganisms. Our findings revealed that levofloxacin-loaded ZnONPs have an effective wide range of antimicrobial effects and could be used for the eradication of pathogenic infections.
Název v anglickém jazyce
Synergistic anti-bacterial effects of green synthesized Zinc oxide nanoparticles with levofloxacin
Popis výsledku anglicky
Nowadays, the emergence of drug resistance was a major problem due to the limited bioavailability and unintended toxicity of antibiotics because of non-specific targeting leading to difficulty to eradicate pathogenic infections. Zinc oxide nanoparticles gain much attention as nanocarriers, due to their non-toxic, eco-friendly, and economical cost, to treat severe pathogenic infections. The purpose of this research was to produce and analyze zinc oxide nanoparticles (ZnONPs) functions using a green synthesis process to evaluate its anti-bacterial and biofilm inhibitory activities against gram-positive and -negative microorganisms. ZnONPs were formed via a green synthetic approach using a seed extract of soybean (Glycine max) and nanoparticles characterization was done using FESEM, X-ray diffraction, UV-VIS spectroscopy, and EDAX. The anti-bacterial and biofilm inhibitory activities of ZnONPs, levofloxacin, and levofloxacin-loaded ZnONPs were determined using agar disc diffusion assay and microtiter plate assay, respectively. Levofloaxcin-loaded ZnONPs showed more potent and statistically significant antibacterial activity than ZnONPs alone against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Enterococcus faecalis. The bacterial inhibition zone of levofloxacin-loaded ZnONPs at 80 µg/ml concentrations was higher in comparison to the standard levofloxacin and ZnONPs alone which showed levofloxacin-loaded ZnONPs possess effective antibacterial activity that prevent the growth of diverse microorganisms. Our findings revealed that levofloxacin-loaded ZnONPs have an effective wide range of antimicrobial effects and could be used for the eradication of pathogenic infections.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
21001 - Nano-materials (production and properties)
Návaznosti výsledku
Projekt
—
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2023
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Journal of King Saud University - Science
ISSN
1018-3647
e-ISSN
2213-686X
Svazek periodika
35
Číslo periodika v rámci svazku
8
Stát vydavatele periodika
NL - Nizozemsko
Počet stran výsledku
10
Strana od-do
102905
Kód UT WoS článku
001085376500001
EID výsledku v databázi Scopus
2-s2.0-85172011998