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Synergistic anti-bacterial effects of green synthesized Zinc oxide nanoparticles with levofloxacin

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F23%3A43924002" target="_blank" >RIV/62156489:43210/23:43924002 - isvavai.cz</a>

  • Výsledek na webu

    <a href="https://doi.org/10.1016/j.jksus.2023.102905" target="_blank" >https://doi.org/10.1016/j.jksus.2023.102905</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.jksus.2023.102905" target="_blank" >10.1016/j.jksus.2023.102905</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    Synergistic anti-bacterial effects of green synthesized Zinc oxide nanoparticles with levofloxacin

  • Popis výsledku v původním jazyce

    Nowadays, the emergence of drug resistance was a major problem due to the limited bioavailability and unintended toxicity of antibiotics because of non-specific targeting leading to difficulty to eradicate pathogenic infections. Zinc oxide nanoparticles gain much attention as nanocarriers, due to their non-toxic, eco-friendly, and economical cost, to treat severe pathogenic infections. The purpose of this research was to produce and analyze zinc oxide nanoparticles (ZnONPs) functions using a green synthesis process to evaluate its anti-bacterial and biofilm inhibitory activities against gram-positive and -negative microorganisms. ZnONPs were formed via a green synthetic approach using a seed extract of soybean (Glycine max) and nanoparticles characterization was done using FESEM, X-ray diffraction, UV-VIS spectroscopy, and EDAX. The anti-bacterial and biofilm inhibitory activities of ZnONPs, levofloxacin, and levofloxacin-loaded ZnONPs were determined using agar disc diffusion assay and microtiter plate assay, respectively. Levofloaxcin-loaded ZnONPs showed more potent and statistically significant antibacterial activity than ZnONPs alone against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Enterococcus faecalis. The bacterial inhibition zone of levofloxacin-loaded ZnONPs at 80 µg/ml concentrations was higher in comparison to the standard levofloxacin and ZnONPs alone which showed levofloxacin-loaded ZnONPs possess effective antibacterial activity that prevent the growth of diverse microorganisms. Our findings revealed that levofloxacin-loaded ZnONPs have an effective wide range of antimicrobial effects and could be used for the eradication of pathogenic infections.

  • Název v anglickém jazyce

    Synergistic anti-bacterial effects of green synthesized Zinc oxide nanoparticles with levofloxacin

  • Popis výsledku anglicky

    Nowadays, the emergence of drug resistance was a major problem due to the limited bioavailability and unintended toxicity of antibiotics because of non-specific targeting leading to difficulty to eradicate pathogenic infections. Zinc oxide nanoparticles gain much attention as nanocarriers, due to their non-toxic, eco-friendly, and economical cost, to treat severe pathogenic infections. The purpose of this research was to produce and analyze zinc oxide nanoparticles (ZnONPs) functions using a green synthesis process to evaluate its anti-bacterial and biofilm inhibitory activities against gram-positive and -negative microorganisms. ZnONPs were formed via a green synthetic approach using a seed extract of soybean (Glycine max) and nanoparticles characterization was done using FESEM, X-ray diffraction, UV-VIS spectroscopy, and EDAX. The anti-bacterial and biofilm inhibitory activities of ZnONPs, levofloxacin, and levofloxacin-loaded ZnONPs were determined using agar disc diffusion assay and microtiter plate assay, respectively. Levofloaxcin-loaded ZnONPs showed more potent and statistically significant antibacterial activity than ZnONPs alone against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Enterococcus faecalis. The bacterial inhibition zone of levofloxacin-loaded ZnONPs at 80 µg/ml concentrations was higher in comparison to the standard levofloxacin and ZnONPs alone which showed levofloxacin-loaded ZnONPs possess effective antibacterial activity that prevent the growth of diverse microorganisms. Our findings revealed that levofloxacin-loaded ZnONPs have an effective wide range of antimicrobial effects and could be used for the eradication of pathogenic infections.

Klasifikace

  • Druh

    J<sub>imp</sub> - Článek v periodiku v databázi Web of Science

  • CEP obor

  • OECD FORD obor

    21001 - Nano-materials (production and properties)

Návaznosti výsledku

  • Projekt

  • Návaznosti

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Ostatní

  • Rok uplatnění

    2023

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    Journal of King Saud University - Science

  • ISSN

    1018-3647

  • e-ISSN

    2213-686X

  • Svazek periodika

    35

  • Číslo periodika v rámci svazku

    8

  • Stát vydavatele periodika

    NL - Nizozemsko

  • Počet stran výsledku

    10

  • Strana od-do

    102905

  • Kód UT WoS článku

    001085376500001

  • EID výsledku v databázi Scopus

    2-s2.0-85172011998