Analysis of selected polymorphisms found within genes involved in bone metabolism signaling pathways with morphometric parameters of bone tissue in broilers

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F25%3A43927236" target="_blank" >RIV/62156489:43210/25:43927236 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.55251/jmbfs.11735" target="_blank" >https://doi.org/10.55251/jmbfs.11735</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.55251/jmbfs.11735" target="_blank" >10.55251/jmbfs.11735</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Analysis of selected polymorphisms found within genes involved in bone metabolism signaling pathways with morphometric parameters of bone tissue in broilers

Popis výsledku v původním jazyce

The constant improvement of genetic tools, mainly due to the influence of genetic selection, leads to a permanent increase in the growth rate of commercial broiler chickens. The result is animals that reach market weight in a relatively short time. However, this often affects the health of the limbs, when such rapid growth is associated with skeletal disorders, when ideal bone development does not occur due to the rapid increase in body weight. While the time it takes to gain slaughter, weight has steadily decreased over the past few years, the time it takes for healthy bone development remains more or less the same. Therefore, studies carried out from the point of view of a better understanding of a relatively little-explored area such as the genetic architecture of bones, can bring insights that can be used in poultry breeding. One of the relatively important signaling pathways for bone metabolism is the RANK/RANKL/OPG and Wnt pathways. Our study is focused on the search for polymorphisms within selected genes (TNFRSF11A and WISP1) of these pathways that might show associations with the traits we are monitoring. Testing was done on 43 broilers, namely fast-growing Ross 308, Cobb 500, and slow-growing Hubbard M22BxJA87A broilers. A total of thirteen polymorphisms were found, three of which were synonymous and five in an intron. Among the found polymorphisms, no one showed associations with the traits we were monitoring.

Název v anglickém jazyce

Analysis of selected polymorphisms found within genes involved in bone metabolism signaling pathways with morphometric parameters of bone tissue in broilers

Popis výsledku anglicky

The constant improvement of genetic tools, mainly due to the influence of genetic selection, leads to a permanent increase in the growth rate of commercial broiler chickens. The result is animals that reach market weight in a relatively short time. However, this often affects the health of the limbs, when such rapid growth is associated with skeletal disorders, when ideal bone development does not occur due to the rapid increase in body weight. While the time it takes to gain slaughter, weight has steadily decreased over the past few years, the time it takes for healthy bone development remains more or less the same. Therefore, studies carried out from the point of view of a better understanding of a relatively little-explored area such as the genetic architecture of bones, can bring insights that can be used in poultry breeding. One of the relatively important signaling pathways for bone metabolism is the RANK/RANKL/OPG and Wnt pathways. Our study is focused on the search for polymorphisms within selected genes (TNFRSF11A and WISP1) of these pathways that might show associations with the traits we are monitoring. Testing was done on 43 broilers, namely fast-growing Ross 308, Cobb 500, and slow-growing Hubbard M22BxJA87A broilers. A total of thirteen polymorphisms were found, three of which were synonymous and five in an intron. Among the found polymorphisms, no one showed associations with the traits we were monitoring.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

40201 - Animal and dairy science; (Animal biotechnology to be 4.4)

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Microbiology, Biotechnology and Food Sciences

ISSN

1338-5178

e-ISSN

1338-5178

Svazek periodika

15

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

SK - Slovenská republika

Počet stran výsledku

5

Strana od-do

"e11735"

Kód UT WoS článku

001511219200001

EID výsledku v databázi Scopus

2-s2.0-105012897222