Nanoparticles combined with cefixime as an effective synergistic strategy against Salmonella enterica typhi

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43410%2F21%3A43919884" target="_blank" >RIV/62156489:43410/21:43919884 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1016/j.sjbs.2021.05.032" target="_blank" >https://doi.org/10.1016/j.sjbs.2021.05.032</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.sjbs.2021.05.032" target="_blank" >10.1016/j.sjbs.2021.05.032</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Nanoparticles combined with cefixime as an effective synergistic strategy against Salmonella enterica typhi

Popis výsledku v původním jazyce

Enteric fever caused by Salmonella typhi has been the most crucial health issue in rural people, especially in Southeast Asia and Africa. Another disease, Salmonellosis, caused by a large group of bacteria of the genus Salmonella, cause substantial economic loss resulting from mortality and morbidity. Higher concentration and repeated use of antibiotics to treat these diseases will likely develop antibiotic resistance among the microbes. The nanoparticle has good penetration power and can kill microbes. Combining two strategies by using nanoparticles with antibiotics kills microbes and reduces the chances of the development of antibiotics resistance. Silver, Nickel, Copper, and Zinc oxide Nanoparticles were chemically synthesized and characterized in this study. Silver nanoparticles at a concentration of 10 µg/ml inhibit all the strains under study. In comparison, silver nanoparticles (16.90 µg/ml), Nickel nanoparticles (83 µg mlMINUS SIGN 1), Copper nanoparticles (249 µg mlMINUS SIGN 1), and Zinc oxide (1614 µg mlMINUS SIGN 1) along with 50 µg/ml cefixime gave maximum zone of inhibition of 35 mm, 19 mm, 31 mm and 23 mm respectively. The antimicrobial assay showed that silver nanoparticles presented good antibacterial performance against all multi-drug-resistant pathogenic Salmonella sp alone as well as in combinations. The present study proved that silver nanoparticles at the lowest concentration along with cefixime could be a possible alternative to control the multi-drug-resistant pathogens.

Název v anglickém jazyce

Nanoparticles combined with cefixime as an effective synergistic strategy against Salmonella enterica typhi

Popis výsledku anglicky

Enteric fever caused by Salmonella typhi has been the most crucial health issue in rural people, especially in Southeast Asia and Africa. Another disease, Salmonellosis, caused by a large group of bacteria of the genus Salmonella, cause substantial economic loss resulting from mortality and morbidity. Higher concentration and repeated use of antibiotics to treat these diseases will likely develop antibiotic resistance among the microbes. The nanoparticle has good penetration power and can kill microbes. Combining two strategies by using nanoparticles with antibiotics kills microbes and reduces the chances of the development of antibiotics resistance. Silver, Nickel, Copper, and Zinc oxide Nanoparticles were chemically synthesized and characterized in this study. Silver nanoparticles at a concentration of 10 µg/ml inhibit all the strains under study. In comparison, silver nanoparticles (16.90 µg/ml), Nickel nanoparticles (83 µg mlMINUS SIGN 1), Copper nanoparticles (249 µg mlMINUS SIGN 1), and Zinc oxide (1614 µg mlMINUS SIGN 1) along with 50 µg/ml cefixime gave maximum zone of inhibition of 35 mm, 19 mm, 31 mm and 23 mm respectively. The antimicrobial assay showed that silver nanoparticles presented good antibacterial performance against all multi-drug-resistant pathogenic Salmonella sp alone as well as in combinations. The present study proved that silver nanoparticles at the lowest concentration along with cefixime could be a possible alternative to control the multi-drug-resistant pathogens.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30107 - Medicinal chemistry

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Saudi Journal of Biological Sciences

ISSN

1319-562X

e-ISSN

—

Svazek periodika

28

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

9

Strana od-do

4164-4172

Kód UT WoS článku

000682931000009

EID výsledku v databázi Scopus

2-s2.0-85106971467