Intracellular phosphorylation of benzyladenosine is related to cell death induction in tobacco BY-2 cells

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A_____%2F03%3A21100010" target="_blank" >RIV/62156489:_____/03:21100010 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Intracellular phosphorylation of benzyladenosine is related to cell death induction in tobacco BY-2 cells

Popis výsledku v původním jazyce

Purines are ubiquitously present simple molecules that participate in transducing signals in all eukaryotic cells. While adenosine, guanosine, and their nucleotides represent intercellular messengers in animals, N6-substituted derivatives of adenine, cytokinins, mediate such signals in plants. Cytokinins, an important class of plant hormones, affect cell growth and division, cell differentiation, chlorophyll senescence, and apical dominance. In the present study we demonstrated that benzyladenosine ([9R]BA) can induce apoptosis upon its intracellular phosphorylation. Accumulation of [9R]BA-mononucleotide was accompanied by production of reactive oxygen species (ROS), intracellular ATP depletion, and these events were followed by the loss of cell viability. Inhibition of intracellular phosphorylation of [9R]BA abolished ROS production, ATP depletion, and consequently prevented cells from death.

Název v anglickém jazyce

Intracellular phosphorylation of benzyladenosine is related to cell death induction in tobacco BY-2 cells

Popis výsledku anglicky

Purines are ubiquitously present simple molecules that participate in transducing signals in all eukaryotic cells. While adenosine, guanosine, and their nucleotides represent intercellular messengers in animals, N6-substituted derivatives of adenine, cytokinins, mediate such signals in plants. Cytokinins, an important class of plant hormones, affect cell growth and division, cell differentiation, chlorophyll senescence, and apical dominance. In the present study we demonstrated that benzyladenosine ([9R]BA) can induce apoptosis upon its intracellular phosphorylation. Accumulation of [9R]BA-mononucleotide was accompanied by production of reactive oxygen species (ROS), intracellular ATP depletion, and these events were followed by the loss of cell viability. Inhibition of intracellular phosphorylation of [9R]BA abolished ROS production, ATP depletion, and consequently prevented cells from death.

Druh

D - Stať ve sborníku

CEP obor

GC - Pěstování rostlin, osevní postupy

OECD FORD obor

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Projekt

<a href="/cs/project/LN00A081" target="_blank" >LN00A081: Signální dráhy u rostlin</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2003

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

7th International congress of plant molecular biology

ISBN

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ISSN

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e-ISSN

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Počet stran výsledku

1

Strana od-do

"xx"-"xy"

Název nakladatele

ISPMB

Místo vydání

Barcelona, Spain

Místo konání akce

Barcelona, Spain

Datum konání akce

23. 6. 2003

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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