Covalent Antithrombin-heparin complex (ATH): an alternative to heparin for arterial thrombosis prevention

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Covalent Antithrombin-heparin complex (ATH): an alternative to heparin for arterial thrombosis prevention

Popis výsledku v původním jazyce

The anticoagulant effect of heparin is expressed through activation of antithrombin (AT). We have developed a novel covalent AT-heparin complex (ATH) that has higher specific activity than unfractionated heparin (UFH) (750 and 180 U/mg, respectively) andinhibits thrombin more rapidly than equimolar concentrations of AT plus UFH (second order rate constants of 3.1 x 109M-1s-1 and 1.0 x 108M-1s-1, respectively). Because of its superior anticoagulant properties, ATH may be better than UFH for prevention ofarterial thrombosis. To explore this possibility, we compared the efficacy and safety of ATH with UFH in rabbit arterial thrombosis prevention and bleeding ear models. Thrombosis in the distal aorta was triggered by a combination of a balloon injury andstenosis produced by application of an external constrictor. Blood flow of the damaged was continuously monitored using an ultrasonic flow probe placed distally to the constrictorAfter 90 min, the extent of thrombosis also was assessed b

Název v anglickém jazyce

Covalent Antithrombin-heparin complex (ATH): an alternative to heparin for arterial thrombosis prevention

Popis výsledku anglicky

The anticoagulant effect of heparin is expressed through activation of antithrombin (AT). We have developed a novel covalent AT-heparin complex (ATH) that has higher specific activity than unfractionated heparin (UFH) (750 and 180 U/mg, respectively) andinhibits thrombin more rapidly than equimolar concentrations of AT plus UFH (second order rate constants of 3.1 x 109M-1s-1 and 1.0 x 108M-1s-1, respectively). Because of its superior anticoagulant properties, ATH may be better than UFH for prevention ofarterial thrombosis. To explore this possibility, we compared the efficacy and safety of ATH with UFH in rabbit arterial thrombosis prevention and bleeding ear models. Thrombosis in the distal aorta was triggered by a combination of a balloon injury andstenosis produced by application of an external constrictor. Blood flow of the damaged was continuously monitored using an ultrasonic flow probe placed distally to the constrictorAfter 90 min, the extent of thrombosis also was assessed b

Druh

D - Stať ve sborníku

CEP obor

GJ - Choroby a škůdci zvířat, veterinární medicina

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2001

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

43th Annual Meeting of the American Society of Hematology

ISBN

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ISSN

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e-ISSN

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Počet stran výsledku

1

Strana od-do

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Název nakladatele

nezjištěn

Místo vydání

nezjištěno

Místo konání akce

Orlando, Florida

Datum konání akce

7. 12. 2001

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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