Covalent Antithrombin-heparin complex coated catheter prevents thrombosis in a rabbit central venous catheter model

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Covalent Antithrombin-heparin complex coated catheter prevents thrombosis in a rabbit central venous catheter model

Popis výsledku v původním jazyce

Central venous cathetrization is an essential part of modern medicine and plays a life-saving role in different groups of patients. However, obstruction due to clotting is a common problem with central venous catheters (CVCs). Surface modification of biomaterials used for manufacturing CVCs has been attempted to prevent thrombus formation. Although heparin coating is widely used for this purpose, it is far from ideal because of problems with leaching of surface-bound anticoagulant, non-uniform coating and variation in anticoagulant activities of the product. We have developed an antithrombin-heparin covalent complex (ATH) using unfractionated heparin (UFH) and antithrombin (AT). ATH has unique anticoagulant and antithrombotic properties. It has much higher anti-thrombin and anti-factor Xa activities compared to non-covalent mixtures of UFH and AT. Based on these characteristics we compared the thromboresistance of ATH-coated polyurethane (PU) catheters with uncoated or heparin-coated c

Název v anglickém jazyce

Covalent Antithrombin-heparin complex coated catheter prevents thrombosis in a rabbit central venous catheter model

Popis výsledku anglicky

Central venous cathetrization is an essential part of modern medicine and plays a life-saving role in different groups of patients. However, obstruction due to clotting is a common problem with central venous catheters (CVCs). Surface modification of biomaterials used for manufacturing CVCs has been attempted to prevent thrombus formation. Although heparin coating is widely used for this purpose, it is far from ideal because of problems with leaching of surface-bound anticoagulant, non-uniform coating and variation in anticoagulant activities of the product. We have developed an antithrombin-heparin covalent complex (ATH) using unfractionated heparin (UFH) and antithrombin (AT). ATH has unique anticoagulant and antithrombotic properties. It has much higher anti-thrombin and anti-factor Xa activities compared to non-covalent mixtures of UFH and AT. Based on these characteristics we compared the thromboresistance of ATH-coated polyurethane (PU) catheters with uncoated or heparin-coated c

Druh

D - Stať ve sborníku

CEP obor

GJ - Choroby a škůdci zvířat, veterinární medicina

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2001

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

18th Congress of the International Society on Thrombosis and Haemostasis

ISBN

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ISSN

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e-ISSN

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Počet stran výsledku

1

Strana od-do

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Název nakladatele

nezjištěn

Místo vydání

nezjištěno

Místo konání akce

Paris

Datum konání akce

6. 6. 2001

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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