In vivo decontamination of the nerve agent VX using the domestic swine model

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F12%3A43870963" target="_blank" >RIV/62157124:16170/12:43870963 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60162694:G44__/12:43874670

Výsledek na webu

<a href="http://dx.doi.org/10.3109/15563650.2012.720986" target="_blank" >http://dx.doi.org/10.3109/15563650.2012.720986</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3109/15563650.2012.720986" target="_blank" >10.3109/15563650.2012.720986</a>

Jazyk výsledku

angličtina

Název v původním jazyce

In vivo decontamination of the nerve agent VX using the domestic swine model

Popis výsledku v původním jazyce

The purpose of this in vivo study was to assess a new, putatively optimised method for mass casualty decontamination ("ORCHIDS protocol") for effectiveness in removing the chemical warfare agent VX from the skin of anaesthetised, domestic white pigs. ORCHIDS protocol consists of a 1.5-minute shower with a mild detergent (ArgosTM) supplemented by physical removal. A standard method of wet decontamination was used for comparison. Experimental animals were divided into four groups (A-D). Two groups were exposed to a supra-lethal percutaneous dose (5 x LD(50); 300 mýg kg(-1)) of VX for 1 h prior to decontamination with either the ORCHIDS (C) or standard protocol (D). A third (B, positive control) group was exposed but not subject to decontamination. Blankcontrols (A) received anaesthesia and the corresponding dose of normal saline instead of VX. Observations of the clinical signs of intoxication were supplemented by measurements of whole blood cholinesterase (ChE) performed on samples of

Název v anglickém jazyce

In vivo decontamination of the nerve agent VX using the domestic swine model

Popis výsledku anglicky

The purpose of this in vivo study was to assess a new, putatively optimised method for mass casualty decontamination ("ORCHIDS protocol") for effectiveness in removing the chemical warfare agent VX from the skin of anaesthetised, domestic white pigs. ORCHIDS protocol consists of a 1.5-minute shower with a mild detergent (ArgosTM) supplemented by physical removal. A standard method of wet decontamination was used for comparison. Experimental animals were divided into four groups (A-D). Two groups were exposed to a supra-lethal percutaneous dose (5 x LD(50); 300 mýg kg(-1)) of VX for 1 h prior to decontamination with either the ORCHIDS (C) or standard protocol (D). A third (B, positive control) group was exposed but not subject to decontamination. Blankcontrols (A) received anaesthesia and the corresponding dose of normal saline instead of VX. Observations of the clinical signs of intoxication were supplemented by measurements of whole blood cholinesterase (ChE) performed on samples of

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

GJ - Choroby a škůdci zvířat, veterinární medicina

OECD FORD obor

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Projekt

<a href="/cs/project/OVUOFVZ200803" target="_blank" >OVUOFVZ200803: SUBSTANCE - Vývoj nového činidla pro dekontaminaci a dezinfekci kůže na bázi micelárních substancí</a><br>

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical toxicology

ISSN

1556-3650

e-ISSN

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Svazek periodika

50

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

5

Strana od-do

807-811

Kód UT WoS článku

000310006900003

EID výsledku v databázi Scopus

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