Percutaneous toxicity and decontamination of soman, VX, and paraoxon in rats using detergents
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F13%3A43874995" target="_blank" >RIV/60162694:G44__/13:43874995 - isvavai.cz</a>
Výsledek na webu
<a href="http://www.degruyter.com/view/j/aiht.2013.64.issue-2/10004-1254-64-2013-2290/10004-1254-64-2013-2290.xml" target="_blank" >http://www.degruyter.com/view/j/aiht.2013.64.issue-2/10004-1254-64-2013-2290/10004-1254-64-2013-2290.xml</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2478/10004-1254-64-2013-2290" target="_blank" >10.2478/10004-1254-64-2013-2290</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Percutaneous toxicity and decontamination of soman, VX, and paraoxon in rats using detergents
Popis výsledku v původním jazyce
Highly toxic organophosphorus compounds (OPs) were originally developed for warfare or as agricultural pesticides. Today, OPs represent a serious threat to military personnel and civilians. This study investigates the in vivo decontamination of male Wistar rats percutaneously exposed to paraoxon and two potent nerve agents - soman (GD) and VX. Four commercial detergents were tested as decontaminants -Neodekont (TM), Argos (TM) Dermogel (TM), and FloraFree (TM). Decontamination performed 2 min after exposure resulted in a higher survival rate in comparison with non-decontaminated controls. The decontamination effectiveness was expressed as protective ratio (PR, median lethal dose of agent in decontaminated animals divided by the median lethal dose of agent in untreated animals). The highest decontamination effectiveness was consistently achieved with Argos (TM) (PR=2.3 to 64.8), followed by Dermogel (TM) (PR=2.4 to 46.1). Neodekont (TM) and FloraFree (TM) provided the lowest decontamina
Název v anglickém jazyce
Percutaneous toxicity and decontamination of soman, VX, and paraoxon in rats using detergents
Popis výsledku anglicky
Highly toxic organophosphorus compounds (OPs) were originally developed for warfare or as agricultural pesticides. Today, OPs represent a serious threat to military personnel and civilians. This study investigates the in vivo decontamination of male Wistar rats percutaneously exposed to paraoxon and two potent nerve agents - soman (GD) and VX. Four commercial detergents were tested as decontaminants -Neodekont (TM), Argos (TM) Dermogel (TM), and FloraFree (TM). Decontamination performed 2 min after exposure resulted in a higher survival rate in comparison with non-decontaminated controls. The decontamination effectiveness was expressed as protective ratio (PR, median lethal dose of agent in decontaminated animals divided by the median lethal dose of agent in untreated animals). The highest decontamination effectiveness was consistently achieved with Argos (TM) (PR=2.3 to 64.8), followed by Dermogel (TM) (PR=2.4 to 46.1). Neodekont (TM) and FloraFree (TM) provided the lowest decontamina
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
KA - Vojenství
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2013
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Archives of Industrial Hygiene and Toxicology
ISSN
0004-1254
e-ISSN
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Svazek periodika
64
Číslo periodika v rámci svazku
2
Stát vydavatele periodika
HR - Chorvatská republika
Počet stran výsledku
7
Strana od-do
211-217
Kód UT WoS článku
000321168600003
EID výsledku v databázi Scopus
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