Induction of matrix metalloproteinase-2 and IL-1 in bovine keratinocytes by histamine.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F13%3A43872472" target="_blank" >RIV/62157124:16170/13:43872472 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Induction of matrix metalloproteinase-2 and IL-1 in bovine keratinocytes by histamine.

Popis výsledku v původním jazyce

Hoof diseases in dairy cows are an important research topic, where the most common problem is laminitis. Complete causes of this disease are still not fully understood. The critical period for the formation of laminitis is after the parturition when is increased demands for milk production and the food composition changes. This can cause a rumen acidosis where the rumen microflora also produces histamine, acting mainly on local microcirculation in hoofs. Many studies in vivo and in vitro have shown thatkeratinocytes are capable to produce matrix metalloproteinase -2 (MMP -2), which expression during laminitis is increased, and the cytokine IL- 1, which triggers a cascade of inflammation retroactively. Purpose of the project was induction cultures of bovine keratinocytes by various concentrations of histamine. Histamine was applied to the medium at a range of concentrations from the physiological to allergic reactions in plasma (0.15 to 1.0 mg / ml). At 24, 48 and 72 hours the concentr

Název v anglickém jazyce

Induction of matrix metalloproteinase-2 and IL-1 in bovine keratinocytes by histamine.

Popis výsledku anglicky

Hoof diseases in dairy cows are an important research topic, where the most common problem is laminitis. Complete causes of this disease are still not fully understood. The critical period for the formation of laminitis is after the parturition when is increased demands for milk production and the food composition changes. This can cause a rumen acidosis where the rumen microflora also produces histamine, acting mainly on local microcirculation in hoofs. Many studies in vivo and in vitro have shown thatkeratinocytes are capable to produce matrix metalloproteinase -2 (MMP -2), which expression during laminitis is increased, and the cytokine IL- 1, which triggers a cascade of inflammation retroactively. Purpose of the project was induction cultures of bovine keratinocytes by various concentrations of histamine. Histamine was applied to the medium at a range of concentrations from the physiological to allergic reactions in plasma (0.15 to 1.0 mg / ml). At 24, 48 and 72 hours the concentr

Druh

O - Ostatní výsledky

CEP obor

GJ - Choroby a škůdci zvířat, veterinární medicina

OECD FORD obor

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Projekt

<a href="/cs/project/QI91A238" target="_blank" >QI91A238: Efektivní postupy při řízení stáda dojnic</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů