The induction of matrix metalloproteinase-2 and interleukine- 1 in bovine keratinocytes using histamine

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The induction of matrix metalloproteinase-2 and interleukine- 1 in bovine keratinocytes using histamine

Popis výsledku v původním jazyce

Claw diseases in dairy cows are the third most important disease group, with laminitis being the primary disorder. To date not all of the causes of laminitis are fully understood. However, it is known that the postpartum period is the most critical time.With the onset of lactation, nutrient requirements significantly increase and this results in the need for major changes to the diet. These changes may lead to the development of ruminal acidosis and consequently increased production of histamine in therumen. Histamine exerts a local effect on microcirculation in the claw. In vivo and in vitro studies have previously demonstrated that claw keratinocytes are able to produce both immunoreactive enzyme matrix metalloproteinase-2 (MMP-2), the expression of which is increased during laminitis, and cytokine interleukine-1 (IL-1), which in turn triggers the inflammatory cascade. The aim of this study was to determine the influence of different levels of histamine acting for different lengths

Název v anglickém jazyce

The induction of matrix metalloproteinase-2 and interleukine- 1 in bovine keratinocytes using histamine

Popis výsledku anglicky

Claw diseases in dairy cows are the third most important disease group, with laminitis being the primary disorder. To date not all of the causes of laminitis are fully understood. However, it is known that the postpartum period is the most critical time.With the onset of lactation, nutrient requirements significantly increase and this results in the need for major changes to the diet. These changes may lead to the development of ruminal acidosis and consequently increased production of histamine in therumen. Histamine exerts a local effect on microcirculation in the claw. In vivo and in vitro studies have previously demonstrated that claw keratinocytes are able to produce both immunoreactive enzyme matrix metalloproteinase-2 (MMP-2), the expression of which is increased during laminitis, and cytokine interleukine-1 (IL-1), which in turn triggers the inflammatory cascade. The aim of this study was to determine the influence of different levels of histamine acting for different lengths

Druh

O - Ostatní výsledky

CEP obor

GJ - Choroby a škůdci zvířat, veterinární medicina

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů