Metabolite profiling of serum from horses with atypical myopathy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F14%3A43873305" target="_blank" >RIV/62157124:16170/14:43873305 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Metabolite profiling of serum from horses with atypical myopathy

Popis výsledku v původním jazyce

Serum samples from 8 horses with atypical myopathy (AM) and 12 control horses were analysed using high performance liquid chromatography (Ultimate 3000, Dionex) with aminopropyl column (Luna 3 mým NH2, 2 x 100 mm, Phenomenex) coupled to tandem mass spectrometry (QTRAP 5500, AB Sciex). A total of 168 metabolites were detected. The results from unsupervised statistical methods show obvious separation of group with AM and control group. The biggest differences were found in levels of glycine conjugates (isobutyrylglycine, hexanoylglycine, suberylglycine, phenylpropionylglycine), acylcarnitines (C5?C18) and purine metabolites (inosine, hypoxanthine, adenine, adenosine). When compared purine and pyrimidine metabolism of controls and horses with AM an elevation of most metabolite levels is observed.

Název v anglickém jazyce

Metabolite profiling of serum from horses with atypical myopathy

Popis výsledku anglicky

Serum samples from 8 horses with atypical myopathy (AM) and 12 control horses were analysed using high performance liquid chromatography (Ultimate 3000, Dionex) with aminopropyl column (Luna 3 mým NH2, 2 x 100 mm, Phenomenex) coupled to tandem mass spectrometry (QTRAP 5500, AB Sciex). A total of 168 metabolites were detected. The results from unsupervised statistical methods show obvious separation of group with AM and control group. The biggest differences were found in levels of glycine conjugates (isobutyrylglycine, hexanoylglycine, suberylglycine, phenylpropionylglycine), acylcarnitines (C5?C18) and purine metabolites (inosine, hypoxanthine, adenine, adenosine). When compared purine and pyrimidine metabolism of controls and horses with AM an elevation of most metabolite levels is observed.

Druh

O - Ostatní výsledky

CEP obor

GJ - Choroby a škůdci zvířat, veterinární medicina

OECD FORD obor

—

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů