Synergistic effects of beta-glucan and resveratrol on platelet aggregation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F14%3A43873320" target="_blank" >RIV/62157124:16170/14:43873320 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Synergistic effects of beta-glucan and resveratrol on platelet aggregation

Popis výsledku v původním jazyce

The aim of this study was to verify these data in growing piglets and newly investigate the role of resveratrol during simultaneous ?-glucan supplementation. 6-week-old Large White breed piglets were divided into one control group (C) and two experimental groups: R (resveratrol) and RG (resveratrol + ?-glucan). Resveratrol isolated from Polygonum cuspidatum root and beta-glucan gained from Saccharomyces cerevisiae were soluted in 15% alcohol and administered to the piglets by gastric probe in a daily dose 3 mg/kg0.75 of body weight. Control piglets obtained only alcohol solution. Blood samples were collected by puncture of v. jugularis and tested for number of platelets, platelet aggregation and speed of platelet aggregation after stimulation by ADP and cationic propylgallate. In comparison to control piglets number of platelets dropped markedly in both experimental groups. After one week of supplementation (R: P{0.05; RG: P{0.01) and after 2 weeks (both R and RG: P{0.01). Aggregation

Název v anglickém jazyce

Synergistic effects of beta-glucan and resveratrol on platelet aggregation

Popis výsledku anglicky

The aim of this study was to verify these data in growing piglets and newly investigate the role of resveratrol during simultaneous ?-glucan supplementation. 6-week-old Large White breed piglets were divided into one control group (C) and two experimental groups: R (resveratrol) and RG (resveratrol + ?-glucan). Resveratrol isolated from Polygonum cuspidatum root and beta-glucan gained from Saccharomyces cerevisiae were soluted in 15% alcohol and administered to the piglets by gastric probe in a daily dose 3 mg/kg0.75 of body weight. Control piglets obtained only alcohol solution. Blood samples were collected by puncture of v. jugularis and tested for number of platelets, platelet aggregation and speed of platelet aggregation after stimulation by ADP and cationic propylgallate. In comparison to control piglets number of platelets dropped markedly in both experimental groups. After one week of supplementation (R: P{0.05; RG: P{0.01) and after 2 weeks (both R and RG: P{0.01). Aggregation

Druh

O - Ostatní výsledky

CEP obor

GJ - Choroby a škůdci zvířat, veterinární medicina

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů